you bet!
Qi Kai and Yang Lan had question marks all the way.
I don't know why Chen Cang thinks the old fox is a good man!
He doesn't look like a good man?
After Chen Cang came back, he said to them, "go back to the laboratory first. I have something to say!"
Qi Kai and Yang Lan nodded at the sound. Although they didn't know what was going on, they... Still followed.
Chen Cang now the system has given several schemes!
Need to try.
But now his ability is limited, and he must work together.
Fortunately, both of them are experienced elders, and all the experiments are done quickly!
The night tedani left.
Chen Cang began to separate according to the system prompt.
He found that Louis corpuscle, as an intermediate product, should have in body fluid markers!
However, according to the special detection methods, he found that it was not completely similar!
In this way
Chen Cang suddenly said to Yang Lan and Qi Kai: "in fact... Louis corpuscle is not a substance!"
"He should contain a variety of substances. We should look for common ground in cerebrospinal fluid, urine and saliva!"
As soon as these words came out, they immediately felt feasible and continued to start crazy extraction and research.
Chen Cang now feels that five days is too short!
But on the fourth day!
The components of Lewy bodies were successfully deciphered: eosinophilic inclusion bodies composed of nerve microfilaments, tubulin, ubiquitin, and a special substance!
The discovery of this special substance immediately excited Chen Cang!
Because he found that this is a soluble protein expressed in presynaptic and perinuclear of the central nervous system, which is closely related to the pathogenesis and related dysfunction of Parkinson's disease.
This great discovery directly made everyone in the office ecstatic!
This is almost a milestone victory!
After the discovery of this special substance.
Chen Cang continued to start the detection according to the auxiliary method of the system.
One after another special potential biomarker proteins were found!
The most important is one, which is a special information symbol transmitted between neurotransmitters.
People found that this was α- Synuclein!
this α- The discovery of synuclein has brought the experiment to a new stage.
Because, through the examination of body fluid markers, this substance was found in cerebrospinal fluid, saliva and urine!
However, Chen Cang and others found in the study.
Salivary secretion decreased in Parkinson's rats, which seems to be related to α- The damage of synuclein affects the autonomic nerve of salivary gland!
Then!
Chen Cang immediately began to study Parkinson's patients with single symptoms and found this α- Synuclein suddenly found that it was not a simple positive correlation!
For a time, it seems α- The research of synuclein has fallen into a bottleneck again!
On the same day, Chen Cang found that rats could not contact Wu Hui to send the patient's blood directly when providing research for their experiment!
Then, Chen Cang linked the words of tedanis!
Perhaps Parkinson's disease is not a degenerative disease.
After thinking of this possibility, Chen Cang suddenly found out.
This tedanis is a complete liar.
Tedanis clearly wanted to avoid himself.
Because after the inspection results, Chen Cang found that:
Parkinson's disease is a neurodegenerative disease, but it is not a simple degenerative disease. A key feature of this disease is damage α- Synuclein accumulates in patients with Parkinson's disease.
Well, the damaged α- How is synuclein produced?
The tedious and boring scientific research makes Chen Cang close to collapse!
During this time, in order not to waste every minute and second, Chen Cang basically had little rest time every day.
All rely on the use of potions to fight hard!
After this scene was seen by Yang Lan and Qi Kai, they had to admire it.
Maybe Chen Cang's success is by no means accidental!
With such a degree of effort, plus excellent personal ability and talent, it is impossible not to achieve results!
Just when Chen Cang's experiment reached an impasse.
Chen Cang suddenly had an idea and began to consult books α- Synuclein itself!
This study really has some different effects.
That is, generally speaking, α- Synuclein is a normal substance.
But why do T cells in the body increase?
What activated him?
Thinking of this, Chen Cang's mind began to run crazy.
α- Synuclein!
Parkinson!
T cells!
Immune response!
……
All kinds of information kept mixing in my mind.
Again and again!
Chen Cang began to guess that it was normal α- Synuclein is unlikely to cause human immune response?
Is it
Is Parkinson's actually an immune response?
In this case, α- Synuclein accumulation produces an immune response, just like an autoimmune response?
Thinking of this, Chen Cang suddenly felt that it was terrible!
Next, he began to consult the information quickly!
Then, through experiments, normal rats were injected with a large amount of extracted α- Synuclein.
But
No response!
This signal transduction factor did not induce a response in the nervous system of rats.
T cells are normal!
Moreover, there was no Parkinson's reaction!
What's that about?
At this time, the system is now in the last few hours.
Chen Cang suddenly found a special substance.
This substance and α- Synuclein is surprisingly similar.
But not α- Synuclein!
Chen Cang quickly asked Yang Lan to come and help with the research!
This study.
Everyone was stunned!
Yang Lan was surprised and said, "Professor Chen, I said... You may find a miracle!"
Chen Cang was stunned: "what's going on?"
Qi Kai is also wide eyed, full of curiosity and expectation!
Yang Lan wrote out the chemical equation of the object.
"This is a kind of after injury α- Synuclein can be folded α- Synuclein! "
"This kind of thing is probably what you said can induce cellular immune response!"
Chen Cang's eyes lit up when he heard it!
He thought of all kinds of information and suddenly said:
"Yes! Normally, neurons have the ability to clear these abnormalities α- Synuclein
"But when neurons are no longer able to clear abnormal α- When synuclein, the autoimmune response in Parkinson's disease is produced. "
"So, in Louis's corpuscle α- Synuclein is probably a broken protein α- Synuclein! "
At this time, Chen Cang suddenly recalled tedanis's words!
He smiled: "you know now that Professor tedanis is not a bad man?"
Qi Kai and Yang Lan were stunned.
Chen Cang said slowly, "just as tedanis said!"
"Parkinson's disease is partly an autoimmune disease!"
"It is this folding that induces this immune disease α- Synuclein! "
Chen Cang didn't say anything: that is... Tedanis may not know that Parkinson's disease is an autoimmune disease!
Otherwise, he wouldn't tell himself the news.
……
……
PS: it arrived at five o'clock. It's a little late. Thank you for your support.