Chapter 427

"Oh?"

Aubrey put his head in front of the photo, tilted his head and looked carefully. He looked up in doubt: "does it look like a stain or paint?"

"Or maybe the blood from cutting your hand?"

Such an idea flashed through his mind, but Zheng Jianguo thought face to face and said with bright eyes: "haven't you tested the ingredients above?"

"After the investigation over there, I sent the things here. I had arranged the test before I came. If there was any harvest, you really helped us."

Looking back from the photo, Aubrey found that Zheng Jianguo didn't continue to look at the photo, but hesitated and said, "agent, I want to send someone to participate in your test process. I don't know if I can?"

"Boss, here comes the coffee."

The closed office door was pushed open. Esther with two cups of coffee opened his mouth to divert their attention. He heard Zheng Jianguo say, "it's her, Esther."

"I don't think your request is necessary. One is that our physical evidence center has the best equipment and the best experts in the world. The other is that you are not a researcher in physical evidence. I don't think so."

Looking back from Esther's delicate to some excessive cheek, Aubrey shook his head at Zheng Jianguo after taking the coffee in her hand. He accepted this person's suggestion because of the other party's identity. As a representative under the node of the establishment of diplomatic relations between China and the United States, if anything happens, it may cause diplomatic trouble, so he got the authorization to monitor his package last time, Of course, letters, postcards and greeting cards are not among them.

"Esther, you go and get the material for my DNA sequence detection paper --"

After receiving the coffee, he kicked Esther out. After drinking coffee, Zheng Jianguo said to Aubrey who looked at him: "according to my latest research results, DNA sequence detection technology can lock their owners through hair, skin tissue, essence and blood.

However, since the paper on this technology has not been published, I can submit the research materials to the experts of your physical evidence center in advance and ask them to do this repeated research.

Then, I will collect and analyze the biomaterials in these photos. Of course, I still strongly hope to provide necessary help in this case. "

"Fine industry and blood?"

He quickly took the coffee cup away from his mouth. Aubrey's relaxed appearance had disappeared. Instead, he appeared as if he could condense water. He said, "can fine spots and blood?"

"If it is not contaminated, of course. I have helped an unknown body find her family in a British laboratory."

After Zheng Jianguo finished, the door of the office was pushed open again. Esther took a folder to the two and said to Aubrey, "please sign this material handover form."

"These are experimental steps. In order to avoid academic disputes and disputes, you need to ensure that these materials are only used for internal research and not for publication."

Zheng Jianguo opened his mouth to Aubrey, and saw him say, "can you do what you say according to these materials?"

"Yes, if the experts in your physical evidence center are really as professional as you recognized, they should be able to do it."

Zheng Jianguo did this because the paper on DNA detection technology was only sent out for a few days. If someone took the information and Aubrey didn't admit it, the leather would be pulled again: "of course, considering that this technology was developed by Esther and I, I don't think your experts can compare with us -"

"OK, I'll send you samples later, and then I'll send another batch of samples in two days. If you can seat these two batches of samples in pairs, I'll allow you to participate in the physical evidence inspection."

Looking at the materials with the thickness of four or five playboys, Aubrey chose to believe him in his own physical evidence center and Zheng Jianguo: "it also avoids the risk of losing your research results."

"Oh, I thought you would ridicule me for overstating my strength."

Zheng Jianguo said and looked at Esther next to him. He saw Aubrey's lips close together, raised his eyebrows, and pointed his hand with coffee at the nameplate on Zheng Jianguo's desk: "you are a Lasker Award winner and director of the Research Institute of Massachusetts General Hospital. Although I know our experts are very professional, I feel that they are not as professional as you, Can you really identify their owners through these - biomaterials? "

"You have said the way, but considering that I will go to Britain next week, you can come directly to Esther. She is the assistant director and my assistant."

The heart said that Aubrey still had some eyes and could quickly hear what was revealed in his words. Zheng Jianguo saw Aubrey and said with a straight face: "although I don't know what technology you are, if you can really do what you said, you will use the power of science and technology to uphold justice for those dead victims."

"Although it is far fetched to speculate that the stain is blood, for example, people who even clean up their fingerprints will certainly clean up the blood, what I think is that the bomber may wipe off the fingerprints because people know that criminals can be found through fingerprints.

So is it possible that he scratched his hand while cleaning up his fingerprints and ignored it without knowing that the blood can analyze DNA? After all, only a few people know that they can find out its owner through the DNA in the blood. Can the things in these photos be tested after completing your test? "

He is not proud of Aubrey's solemnity. Of course, Zheng Jianguo knows the importance of forensic DNA technology. Cases decades ago can rely on the analysis of biomaterials to lock suspects. If he announced the treatment of Helicobacter pylori and the transmission route of HIV in advance, he saved hundreds of millions of people, The emergence of this technology will help the law to try those criminals.

"OK, if you don't say I forgot my intention, I'll go back and inform them. Director Zheng, thank you for your advice."

Suddenly remembering the purpose of this visit, Aubrey put down his coffee and leaned out his hand to Zheng Jianguo. Zheng Jianguo shook hands with him and sent him to the door of the office. Waving his hand, he saw him running away quickly. Esther's voice came from his side: "boss, are you not afraid of him taking the materials?"

"It's no use taking it away. Primer design, DNA extraction, sample PCR, PCR fragment purification, and then genetic analysis -"

Zheng Jianguo leaned out his right hand and shook it into a fist. After saying one step, he raised a finger. Finally, after five steps, he glanced at her and said with a sneer: "Aubrey said that their physical evidence experts are experts. Do you think those people are really experts? If this technology is really so simple, will I vote for nature? "

"Then you want to give him these materials?"

Esther is a little silly. Of course, she knows that each of the five steps mentioned by Zheng Jianguo is enough to publish articles. That is, Zheng Jianguo disdains to do so after a lot of top journals are published. To be exact, she doesn't like it: "first, even if the people in the physical evidence center are really experts, they really repeat our experiments after getting these, Do you think our paper may not have been published? "

"Well, if everything starts from scratch, primer design is not easy to learn. Apart from DNA extraction, they have to do sample PCR for weeks or months? Will your thermal circulator be on the market? "

Esther's small face showed a look she thought it was, but after she finished, she looked around and looked at Zheng Jianguo with a pair of big and blue eyes: "do you want this technology to attract Aubrey's attention?"

"No, I want to see if he is self-motivated. In addition to playing a big role in crime, this technology can also be used for paternity testing. I want to give you more choices. Recently, I feel that with the help of the thermal circulator, the gene field will be a new hot spot in the future."

If he hadn't been targeted by the bomber, Zheng Jianguo didn't want to have anything to do with the FBI. One is that he has a lot of secrets, and the other is that he is afraid of being mistakenly thought to be bought by domestic intelligence agencies. In this way, when he goes back, he may encounter any trouble, especially with Charlie and Li Lijun.

In fact, after seeing the bomb triggered by matches, Zheng Jianguo didn't pay much attention to the bomber. Of course, this doesn't mean that he can find out the man through the DNA on the bomb, but through the rough earth bomb, it can be seen that it was not done by professionals, that is, it was not done by the FBI, CIA and intelligence personnel on the other side of the sea, I'm afraid it's a high school student who failed even a chemistry course.

As far as Zheng Jianguo is concerned, as long as these organizations don't take action, he believes that the barrier built with money will ensure his basic safety. As long as he is safe, he can choose to smash the other party with money.

Of course, although the safety factor of the Lasker prize is high, it is still not as safe as the Nobel Prize. The reason why Zheng Jianguo announced the technology for detecting DNA sequence so quickly is because he wanted to advertise the PCR technology. Although he planned to use the human genome program to promote the application of PCR, now he has invested all his money in the oil contract, You can only choose to postpone this plan.

Although the plan was delayed due to the problem of funds, Zheng Jianguo did not forget to look for potential opportunities all the time. Obviously, the suddenly emerging bomber was a good entry point, so he was so generous that he even took out all the information. He didn't want Aubrey to be much smarter than he thought: "of course, in fact, I think Aubrey was due to the problem of cost, Just chose to give up taking these materials. "

Since he had already started the preparation of the human genome, Zheng Jianguo had already made statistics on relevant technologies at this time. Not to mention the number of 3 billion base pairs in 25000 genes in his memory, it would take six to eight weeks to sequence each gene, The possible contamination of genes by isotopes in Southern blotting, which is still a cutting-edge technology at present, is enough to lead to the failure of the whole detection.

When there is no thermal circulator available, the consequence of failed sequencing is that it needs to start from the extraction of genes and start again after two to three weeks of artificial PCR.

During this period, the consumption of various materials is as high as two or three hundred dollars, not counting a researcher's salary of six hundred dollars a Friday. After all, he is a researcher who has mastered the artificial PCR technology.

But even according to the impossible probability of success at one time, 25000 genes can be calculated in the shortest six weeks, which is as high as 150000 weeks. You know, it takes only 52 weeks a year, and it takes 2000 years to complete the fraction after removing the hundreds.

At this time, scientists believe that humans have billions of genes.

Therefore, after Zheng Jianguo's initiative half a year ago, he did not really see the dawn of the human genome project until he successfully developed a thermal circulator based on PCR technology.

The reason for this is that before the PCR thermal circulator came out, the results of artificial PCR for two to three weeks only made the gene amplification ten times or so.

But if we leave these tasks to the thermal circulator, in just two or three hours, it will be enough to amplify genes or fragments to 100000 times, millions of times.

In addition to direct observation by electrophoresis, the amplified genes or gene fragments can also be further analyzed for genes, without the need for manual PCR due to insufficient concentration. The efficiency is directly increased by thousands of times.

Only after solving the problem of gene concentration, the artery of the human genome project still has insufficient researchers. Although the Sanger detection method invented in 1977 has been developed for three years, it still belongs to cutting-edge technology at this time. The researchers who master this technology are paid seven or eight hundred dollars a week.

Although the FBI's physical evidence center has very professional experts, Zheng Jianguo believes that the number of researchers who have mastered this detection technology will not exceed one slap, which is calculated by him.

However, from Zheng Jianguo's point of view, this is not a big problem. The reason why this technology is not popular is that no one needs it. Just like the service industry in the commercial market, there will be demand for it. In the field of scientific research, there will be hot spots followed by researchers. In addition, when Zheng Jianguo opened this hot spot, It must attract enough researchers to apply.

Especially now, after Zheng Jianguo became the winner of Lasker's 1980 Clinical Medicine Award: "unfortunately, all the money has been thrown into the oil contract, otherwise he can announce the launch of the human genome project at the award site at the end of the month. Do you want to close your position in advance and put forward some money as start-up funds?"

If the human genome project is announced at the award ceremony, Zheng Jianguo believes that the project will spread to the researchers as quickly as possible through the word-of-mouth of all the guests present. He can think that the rise in oil is the biggest opportunity to make money in the next five years. He feels a little hesitant: "is money important?"