Chapter 1262

When Zhang Fan and his party were on the plane.

The Lancet published a heavyweight paper on intestinal cancer.

And it was published by tea element hospital. Previously published papers are important, but they are not big inventions.

Either a small new discovery or an innovation in surgical technology.

This kind of paper is the thick accumulation in the thick accumulation of thin hair. It is not helpful for doctors to hire professional titles, and it can not be promoted to the attention of people outside non hepatobiliary disciplines.

But the paper on intestinal cancer published this time is different.

Marubeni has been cooperating with tea for almost a year.

From the beginning of cooperation, MARUKI first called on patients from their own country. At the beginning of the first wave, tea vegetarians were stunned because they found that there were many bowing people in the street.

Colon cancer is the third largest cancer in the world. Moreover, there are a lot of pill countries. I don't know whether it is a genetic problem or eating too much sashimi. Their country even has this problem in the capital of yuan.

It is said that there is a joke that one year the Prime Minister of Marubeni reported to their emperor. As a result, he first ran to the bathroom seven or eight times in two hours.

The emperor was also curious and thought that the prime minister liked their toilet.

Therefore, when Marubeni saw Zhang Fan's operation level in the intestine, it began to vigorously cooperate with the tea element hospital.

Originally, I wanted to lure Zhang Fan to Marubeni, but after 80, I was in tunnel warfare and mine warfare. Zhang GA, a small soldier, broadcast again and again when it comes to holidays. The generation who grew up is definitely not the same as the one who plays chess.

It's impossible to go to meatball country.

Therefore, Marubeni can only cooperate with the tea vegetable hospital.

But medical research is not expensive in the laboratory.

It's the money for clinical trials.

For example, a new drug needs to be developed.

When developing this thing, the goal is to focus on the cardiovascular system.

First, animal experiments in vivo, and planing experiments.

But animals can't communicate with people when playing. They can only observe the target organs.

As a result, when it comes to the human body, the cardiovascular function is too general.

But doctors were surprised to find that this thing was effective for the third leg.

To tell the truth, if it didn't work on the third leg, Wei Wei estimated that he would have died directly in the first round of clinical trials that year.

These preliminary tests and R & D are not the most expensive.

It is often expensive to enter the clinical trial stage. Many new drugs die here.

First of all, there must be a large number of specimens for this kind of test. This kind of specimen is human, so many pharmaceutical companies go to San Ge for clinical trials.

It's not the third brother's clinical trial, but other people's medicine is cheap.

Hundreds of millions or even billions of R & D expenses are actually spent on several rounds of clinical trials.

Therefore, it is too expensive for Marubeni to bring patients here. Then he encouraged the patients from Outer Mongolia to come.

For a time, after the bow, a group of Mongolian people wearing similar but different clothes appeared in the tea vegetable street.

The local elderly Mongolian people looked at it and said, isn't this the offspring who were herded by us hundreds of years ago.

To tell you the truth, the Mongolian people in China say that they are golden. The outside group used to herd them.

With a lot of investment, we finally saw the results.

Colon cancer is easy to develop and metastasize, and the mortality is extremely high.

This time, the team of tea and pill countries finally found a factor for colon cancer metastasis.

The most terrible thing about cancer is not the growth rate of this thing. According to the current surgical level, how fast you grow can be cut or embolized as long as you are not an important organ.

But the terrible thing about this thing is that it has big long legs. It will run and infect.

When it spreads, it is particularly terrible. The first way is lymphatic metastasis. Lymph is originally the immune system. Once it is destroyed by cancer, it will directly affect the body.

Therefore, when the doctor looks at the touch and listens to the touch, there is one item of touching the lymph. Especially when the doctor touches your steamed bread, it's not playing a hooligan. It's to see if your lymph is swollen.

Of course, there are scum.

In addition, there are blood vessels where there is meat. Once it enters the blood vessels, there is no chance of surgery. It can only be poisoned by radiation and drugs. Often, the result is that cancer is not killed, and drugs and radiation hang people first.

The third direct invasion, such as rectal cancer, why surgery is terrible, because rectal cancer directly invades nearby organs.

For example, men's prostate, urethra, women's genitalia and uterus, together with levator ani muscle, surrounding skin and bladder.

Therefore, radical resection of rectal cancer is quite terrible. It directly means digging all the organs near chrysanthemum.

In this operation, chrysanthemum looks like a sunflower with a large washbasin, and then all these organs are dug out. What you can see directly is the intestines.

The last one is to plant like dandelion. After cancer cells mature, this thing can swim in the body like dandelion seeds, and settle down wherever it falls.

But what is the reason that cancer factors can run and metastasize.

The trouble is that different cancers have different causes of metastasis.

This time, the team of catechin and Marubeni found the cause of colon cancer metastasis.

Creatine!

Creatine is not only a catalytic enzyme for energy conversion in mammals. It's also an energy buffer.

To put it simply, for example, your wife discovered you were stealing food, and then you began to lie. Your brain was running at high speed. As a result, ATP was not enough, and ATP was equal to the gasoline of the human body.

This stuff is not easy to preserve when it is produced, so it is often stored in the form of fat. When it is stored, everyone says it is good, but once it is used, it will decompose, so when the energy is not enough.

When the brain is about to shut down, creatine is replaced.

For example, many iron rolling lovers want to make their muscles bigger, or make tortoise shells appear on their stomachs.

Just supplement creatine.

The tea element hospital found that creatine is good for normal people.

But in patients with colon cancer, creatine also has a bad side.

This device can promote cancer metastasis by activating the signal pathway of smad23 caused by single-stage spindle.

In other words, cancer cells originally ate leek boxes in the colon. As a result, creatine hands are cheap, or there is too much energy. It shows its ability to open a highway between the intestine and other organs that can let colon cancer run.

It's that simple.

What diseases fear is that they don't know the mechanism and what this thing is all about.

For example, SARS in those years, why was it so terrible, because we couldn't find out what it was.

But once found, there is always a way.

Now, although colon cancer has not found why it appears, it has found how it runs.

Although this can not completely eliminate colon cancer, this discovery has been quite powerful.

If you can cut off its way of running, even if colon cancer occurs, it is also a lamb to be slaughtered. If you are a little disobedient, the doctor can cut off the intestines with lesions.

Therefore, this discovery is quite cow. It can be said that once a creatine drug corresponding to the inhibition of colon cancer is developed, the colon cancer will be directly limited to the colon.

After the success of the experiment of the tea element and pill team, contradictions broke out between the two sides.

This is the so-called common problem. Can we share wealth with wealth.

What Marubeni means is that they are the main force of the experiment.

They even paid for the test tube.

Tea vegetable side, led by Ren Li, of course, can't let go.

After arguing all morning, the two sides finally compromised.

Because there are many research teams around the world, we must send the paper early after success, otherwise it will be too late to cry if the paper spy gives it to other teams.

Then, the first author is a professor of marukuni, but the wonderful thing is that the corresponding author is Zhang Fan, yes, it is Zhang Fan.

Because there is no colon expert and scholar on the top beam of tea. But it was impossible to let go, so Zhang Fan stood up.

Moreover, because the early operation directly depends on Zhang Fan, although Zhang Fan has little effect in the experiment, they can't study without Zhang Fan's early accurate separation of cancer.

Therefore, Zhang Fan became the corresponding author.

In fact, the first author of a paper is often very important, but the corresponding author is not bad.

The first author is often the main force of the experiment, the experimenter from beginning to end.

The corresponding author often has an idea, perhaps participated in the experiment or did not participate in the experiment. Therefore, the general correspondents are often teachers or mentors of the first author.

However, he must be responsible for the experimental results and papers. It's good to say that if there is a problem with the paper, the journal does not contact the first author, but the corresponding author.

The second author is the one who has some weight.

The rest, third, fourth, fifth and sixth, are actually members of the atmosphere group.

After the paper was published, almost some famous people from Johnson & Johnson, Roche, Pfizer and Novartis began to pay attention.

In the past, some researchers paid attention to tea element in the research and development of equipment. Now it is different. They directly began to put Zhang Fan and tea element hospital into the library of scholars they focus on.

After the paper was published, GlaxoSmithKline of Mishima learned that Zhang Fan was coming to Mishima. They didn't pay much attention.

Because people are not very prominent in the drug research and development of the liver.

But people can directly represent the highest pharmaceutical level in terms of respiration, gastrointestinal tract, metabolism and anti-tumor.

So when you see the new discoveries of tea and meatball country. They began to pay attention.

The head office directly began to contact the Royal Hospital to inquire about Zhang Fan's itinerary.

Moreover, we should also be prepared to spend great efforts on public relations with Zhang Fan.

Enterprises do not see blood without a knife.

But the hospital in Mishima doesn't think so.

"Do you think Dr. Zhang Fan, who said tea element, is suspected of counterfeiting. It's incredible that a liver and gallbladder expert can publish a world-class colon paper. "

"Yes! He can even become a corresponding author. The first author is also a famous professor in Marubeni! "

In the Royal Hospital, the director and professor of hepatobiliary Department watched the newly published paper together.

"Expand the number of speakers. Involve gastrointestinal experts. " The president of the Royal Hospital said directly.

"However, if Zhang Fan really makes a fake, will it affect our reputation!"

"No, no, no, if he is a fake and is seen through by our hospital, it will give us more honor."

"Good! Do you need to invite from other countries? "

"Do we need experts from other countries for our big three island Empire?"

The Royal professor said proudly.