Chapter 1328

A drug, here specifically refers to a compound drug. If you want to enter the clinic, you can learn from the Scriptures like Lao Tang. Anyway, you can't escape through mountains and rivers.

The simplest, AIDS clinical trials have failed more than 200 times, and the money in it can almost be counted as if the water in the Yellow River has been pouring out. Others, such as herpes, also failed.

Before the third phase, many drugs felt like seed players. As a result, they entered the third phase. The whole thing was a silver like Pewter gun head.

Generally speaking, the trials before the third phase were all literary dramas, but after entering the third phase of clinical practice, this is the work of real knives and guns. Whether it is OK or not, this thing will be shown at this time.

Around the world, more than 10000 medicinal compounds will be developed a year, and then about 200 to 300 can enter animal experiments, and no more than 10 can really enter phase III clinical trials.

It can be said that one out of ten thousand.

The tests before the third phase are often qualitative. For example, if you eat this thing, it will lead to other diseases. For example, the drug tea element has found a pair that can make mice stay overnight. This is one of them.

Seriously, the research is to treat intestinal tumor suppressor drugs. As a result, the skin of mice has been stripped off, which is a failed chemical synthesis.

What is the third phase test? The third phase test is simple. The first phase toxicology and pharmacokinetics depends on the drug toxicity and metabolic mechanism; In phase II, select the dose, determine the dose of the drug through the window between the maximum acceptable dose and the minimum effective dose, and preliminarily measure the effectiveness and safety of the drug; Phase III, large-scale effectiveness and safety test to verify that the drug can treat diseases and be used safely.

After passing these three trials, we can apply to the regulatory authorities for NDA. In fact, there are still four phases. However, the fourth phase is fooled by everyone. The fourth phase is the market response and some individual requirements of the regulatory authorities. It's OK to have money.

Therefore, if the general drug instructions tell you to take it according to the measurement, you can take it according to the measurement. Others don't say that there is gold in it, but you have to take one when you take the medicine. Do you think he can't do the test, or do you think you are lucky.

Drugs are toxic. Especially for some drugs, the window of safety measurement is very narrow. If there is more, it will change from treating diseases to killing poisons.

Moreover, before the clinical experiment, once the drug characterization is passed in the laboratory, it is necessary to conduct two appropriate animal experiments in order to give the data for human experiment.

This thing is more popular. It is to find human cousins who don't have five clothes to experiment. Although the regulatory authorities of various countries do not specify an animal, they have a requirement: animal experimental data related to pharmacology.

That's why I said plainly, cut the monkey!

Small molecule drugs generally require the test data of rodent species, and strictly use slightly larger mammals, such as mini pigs and dogs.

And Zhao Yanfang and their cousins who don't have five clothes, primates!

Therefore, although I am happy now, the pressure is not small.

In fact, the current situation is that just after the Long March, you have to die in the Jinsha River. The pressure is really not small, but there is hope now!

Therefore, Zhang Fan now tells himself that he must hold fast, hold fast, and never swing. If he really swings down, the boss of the tea vegetable government may really cry.

All the way west, on the highway, kuluze galloped steadily. Both women were making up for sleep. I didn't know that they stole some rice from someone's house last night.

Zhang Fan listened to the Xihai love song of the Phoenix Group and ran all the way towards tea.

After Tianshan, the scenery is different immediately.

If the scenery of the bird market is similar to that of Jiangsu Province, in addition to the flat land, it is also mainly earthy yellow. On the bare mountains, like children without hair, they tie up a chicken and sing an elephant.

But once you cross the Tianshan Mountain and enter the tea boundary, the scenery is different. The expressway shuttles through the Tianshan Mountain. Looking at the snow mountain in the distance, you can feel a little cooler in summer. On both sides of the road are all kinds of fir trees, which are lush and straight into the sky.

Really, extremely beautiful.

After entering the tea vegetable land, he obviously didn't get home, but Zhang fan can obviously feel that he seems to be home.

Zhang Fan drove into the hospital.

……

The hospital's laboratory was overcrowded. Lao Chen looked out while wiping the sweat on his forehead. When he saw Zhang Fan's car, he quickly said, "Zhang Yuan is coming, Zhang Yuan is coming."

In addition to Ouyang, others are ready to welcome Zhang Fan.

Zhang Fan entered the laboratory and looked, Ho! The leaders in charge of health came and rubbed their hands. It is estimated that sweat beads have been rubbed into medicine pills.

"If you don't come today, I think the doors here will burst." Ouyang looked at a group of people around him reluctantly.

"What about the report? I'll look at the report first."

Zhang Fan hurriedly asked.

"I'm in charge. Before you come, the report is sealed. No one can read it first." Ouyang said.

"Take it out quickly, Zhang Yuan is coming!" The leader in charge of health is like a junior high school student and the owner of the video hall to play a midnight film. He is quite dissatisfied with Ouyang.

After a while, the report came over. Zhang Fan found an office and opened it to have a look.

Ouyang whispered to Zhang Fan, "the security of the laboratory is estimated to be out of order."

"It's not necessary. It hasn't reached phase III yet." Zhang Fan didn't understand.

"What do you know? Something's really going to happen. You have no place to cry. Look how complicated this place is.

Marubeni, golden Mao, golden mean, digital, and doctors from various places. Some don't. do you know what people think? "

When Ouyang said this, Zhang Fan thought the old lady was right. There's going to be a problem. Who is he looking for to cry.

"OK, you're right. Let the tea vegetable government come forward?"

"No, we don't have a good relationship with road airlines. They borrowed our plane last time. I mean, let road Airlines send a company!"

"Well!" Zhang fanhan came down. Ouyang's tone is too big. A company, a hundred people, you haven't done anything yet. You just want a company. If you want to be able to do something, do the border military region have to move to the tea vegetable hospital!

"OK, OK, OK, I'll ask Lao Chen to contact me later. If you can save your face, you can use it less and save it for the critical moment. "

Zhang Fan comforted the old lady. The old lady was very useful!

Open the report, Zhang Fan has a little egg pain. He read the report too hard, almost all in English, and there are a large number of chemical molecular formulas.

Big head!