Chapter 782

When Arnold returned to the company, he called the company's scientific research team together, and then described in detail what he saw in Huarui laboratory. Although he omitted the part that could not be said in the confidentiality agreement, his description was enough for researchers to refer to.

In fact, the confidentiality agreement is Yang Rui's precaution. In his laboratory, there is no mysterious information that can be taken away when he sees it.

Arnold finished, then asked, "do you think there's hope? Yang Rui's desferridone project. "

After several researchers had a discussion in a low voice, the new chief technology officer fan lunding said: "as far as the conditions are known, there is no problem in terms of active substances when deferrone is synthesized. As long as the active substances are made, it is necessary to continue to do so. "

Valentine came to replace Trapp, who, as a well-known biological and chemical expert, just came to help when he started in China.

Compared with the professor of Sheffield University, van Lundin's qualifications are slightly inferior. His most remarkable achievement is that he participated in the Olympic Games as a rower from Cambridge, that's all.

Fan lunding didn't have much contact with Yang Rui, so he only considered scientific research and said, "I don't think it's a good idea to do drug research in China. Even if he wants to sell his company at a good price, it's not worth doing original drugs. If we take the route of rare drugs, we can really save a lot of trouble, but it's still very troublesome and not an appropriate choice. "

"He has chosen. I think the key to the problem is, do you think Yang Rui can succeed?" Arnold asked seriously. It's a key question.

Fanlunding thought for a moment, but he didn't dare to deny it. He said: "it's hard to judge, but you know, even if 100 active substances are synthesized, they may not pass the animal test, let alone the human clinical test. He is far from success."

Other researchers also nodded, saying they were not optimistic about Yang Rui's research.

The researcher of Jielikang in China is mainly responsible for solving the production problems of coenzyme Q10 plant, and helping Chinese partners to build a new plant. He has also dealt with Yang Rui.

However, they used to regard Yang Rui as a figure in the academic circle. Now they see him enter the industrial circle, revealing the inherent prejudice of the industrial circles against the academic circles.

"It's not so easy to develop original drugs. It's very difficult for Yang Rui to succeed."

"Not likely to succeed."

"Maybe he's trying to sell us the active substance he made?"

"You have to pass the animal experiment before you can sell it."

After listening to their discussion, Arnold also changed his mind and said, "as far as I know, Yang Rui's record is very strong. I'm afraid he's got a card in his hand to make ferroketone."

"It's no surprise that every researcher is confident of success before they start the experiment," Valentine said with a smile. As a result, you can see, how many drugs can succeed in the end? There are too many outstanding researchers in our company. Who can guarantee that their next new drug will be successful? "

Arnold hung his head and thought. Suddenly, he made an expression of what he thought of. He shook his head and asked, "Valentine, I remember you used to do new drug development?"

"Yes."

"What happened?"

"When the project failed, the company reorganized the project team, failed again, the company reorganized the team, continued to fail, and the company made additional investment, but still failed, and the project team finally dissolved." In the most concise way, Valentine describes the seven years that once belonged to him.

As if unconscious, Arnold asked, "what have you done?"

"Clinical phase II."

"From target screening, to drug synthesis, to animal experiments, then clinical phase I, clinical phase II... All the way, to the final stage to give up, a little regret." Arnold doesn't know much about scientific research, but he knows a lot about project management.

"It's a pity, but the effectiveness test failed. If we continue, we will only spend more money." Valentine spoke from the standpoint of the company without expression.

The first phase of the clinical trial is the drug safety trial, which is usually conducted in 20 to 40 healthy volunteers and costs less than $1 million.

The second phase of the clinical trial is the drug efficacy trial, which requires 100 to 300 patients, usually more than $20 million.

As for the third phase of clinical trials, it is the large-scale verification stage of drug safety and effectiveness. Since it is large-scale, there will be a large number of people. In the testing of non rare drugs, the number of people in the third phase of clinical trials will usually increase to 20000, and the cost will reach an amazing $100 million or more.It can be imagined that no company will rashly promote the progress of clinical trials before they are quite sure.

Arnold thought of this and thought about what Yang Rui is doing now. He could not help but pull Valentine aside and whispered, "can you think of a way to make Yang Rui accelerate the research progress and expand the research scale?"

"Why?" Valentine was surprised.

"You don't want to manage, just do what I say." Arnold thought and laughed.

The main purpose of his coming to China is to purchase the catalyst formula of coenzyme Q10. Two months' delay is almost his limit.

However, Yang Rui does not seem to be affected by the delay, which makes Arnold not only depressed, but also worried.

In his opinion, the main reason for this problem is that Yang Rui does not have an urgent need for funds.

At present, Yang Rui's biggest expense is lawyer's fees, which is nearly one million dollars a month, which fully proves the seriousness and playfulness of American law. However, several million dollars of dividends from Jericho each quarter fall into Yang Rui's hands, which is enough to solve the problem of lawyer's fees.

In this way, Yang Rui naturally has no impulse to sell catalyst patents urgently.

However, if Yang Rui invests too much in the research of new drugs, things will be completely different.

Arnold is not completely sure how many shares Yang Rui has in Huarui company, but through various understanding, Arnold determines that Yang Rui has shares. The lawyer who helped Yang Rui set up the company at that time was the relationship between Jericho and Arnold. Although Arnold couldn't ask for specific details, there was always rough news.

Van Lundin didn't understand Arnold's purpose, so he only said from the perspective of research: "when researching new drugs, everyone will carefully control the progress and scale of research..."

"Yang Rui hasn't done any new drug research before. If you give him some advice, maybe he will carry it out."

"Are you going to send me to Huarui Laboratory for guidance?"

"Well, help them advance the progress of the experiment, push faster..." the initial cost of new drug research is not high, but the later cost is bottomless.

Valentine didn't think it was useful, but he agreed.

The next day, fanlunding arrived at Huarui laboratory and found that he was really wrong.

The research progress of Huarui laboratory is much faster than he imagined.

……