Chapter 807

At eight in the evening.

President Liu came to the police station in a hurry on his bicycle and showed the instructor his work card and letter of introduction.

Li Zhangzhen came with him,

The instructor of the police station suddenly realized: "I said you look familiar. You are Yang Rui. I heard that you want to win a Nobel Prize."

"It's nothing." Yang Rui will not admit that the nomination has not come out.

"I'm sure I remember correctly. It's just a prize." The instructor patted his head: "you see my dog's memory, I can't remember where the excrement is buried."

Yang Rui looked at him speechless and said to himself: if you eat what you bury, don't treat it.

The aunt of the neighborhood committee was still a little unconvinced. She stared at President Liu's work permit for a long time and said, "just such a young man, is he from Peking University?"

Director Liu laughed: "Yang Rui is a student in Peking University. He must be a young man."

"Such a young man, do you want to talk to foreigners? You have a big heart. " The aunt of the neighborhood committee said, and then reproached: "talk about things, talk about things. Don't you find a better place to talk about things with foreigners? What's the use of talking about it? We in China, we want you to make a mess of it, and let foreigners listen to it. Hey, it's all boasting... "

Aunt nagging, Dean Liu can only stretch his neck to listen, otherwise how to do? Fierce than, he does not necessarily win, roll sleeve fight certainly can not, to find the police, the police station instructor standing next to it.

After half an hour, Yang Rui and others were able to walk away.

A few foreigners are very excited. They all think it's a rare life experience. They have the pleasure of looking down at the piranha just after swimming in the Amazon River, watching TV interviews with drug dealers just after wearing it from the slums of Mexico City, boarding the plane just after graffiti in Pyongyang and gazing at the statue of the leader.

However, there is no way to continue the negotiations. In fact, there is no need to carry out the negotiations. The terms discussed in the front are all informative. In the end, who is willing to sign a contract, who can agree to Yang Rui's terms, or who wants to bargain again, will have to be decided later, even the company's chief executives and even the board of directors. When such a gambling agreement is negotiated, the minimum situation is to pay US $1 million and get nothing. It may also pay US $20 million or more to get more than one active substance through clinical phase I. of course, it may also cost tens of millions or even US $100 million to get a drug through clinical phase II.

If it's $1 million, all of you will be able to decide, but you're not going to lose money. Since the amount involved in signing the contract may be hundreds of millions, you have to have someone with such authority to approve it. Naturally, you can't decide on the spot.

Of course, although no decision was made on the spot or even a paper agreement was signed, everyone present was very happy.

In addition to one more experience, Yang Rui's performance also enhanced their confidence in deferonone.

Indeed, desferridone is not a blockbuster, let alone a big killer like penicillin. Unfortunately, how many people in the whole pharmaceutical industry thought they could sign a new penicillin—— Perhaps in the dream, we have such a dream, but wake up, we have to face the reality.

It's like architects dream of building the world's first building. We all take this as our lifelong goal. Who can do the design and sign the contract every time?

In the same way, we all know that the annual sales of a blockbuster is more than $1 billion, and one can make a lot of money. When signing a contract, you can't just look at the blockbuster.

Lobster is delicious, you can't just eat lobster.

In this era when the whole industry can only produce double-digit new drugs every year, lobster should be grasped in the hand, and steak should not be let go. Even if lobster is grasped in the left hand and steak is grasped in the right hand, when you see steamed bread, you have to step on it. Otherwise, who knows if lobster and steak are finished, it will be broken, or FDA will have a brain pumping, How to bury the lobster and steak? This happened not once or twice, otherwise, Wall Street would not value the drug reserve capacity of pharmaceutical companies so much.

Because of this, in this industry, the original drug companies do the most targeted new drugs. For example, in order to treat chronic myeloid leukemia, biologists found that bcr-abl, a molecular target, may have therapeutic effect. Therefore, the laboratories of pharmaceutical companies carried out high-throughput screening, and produced 30 to 50 active substances, The animal experiments and clinical trials were started step by step. Finally, imatinib appeared and seemed to achieve the expected goal. So, is this target completed?

Of course, it's impossible. It just shows that the molecular target bcr-abl is really effective as biologists say. Therefore, more pharmaceutical companies will set foot in this field, and dasatinib and nilotinib are born one after another. The relationship between these drugs is just like the relationship between the last seven compounds of Yang Rui.If all the seven compounds Yang Rui made finally pass the clinical trial, then in theory, seven kinds of desferridone can be produced.

As a matter of fact, it is common for pharmaceutical companies that two or three or more compounds have passed clinical trials. This is not a bad thing. For pharmaceutical companies, on the one hand, they can choose the best compounds to make drugs; on the other hand, they can wait for the patent protection period to come, Register a generic drug by oneself, even register multiple drugs by oneself during the patent protection period, so as to occupy the market and raise the threshold.

Because the pharmaceutical industry is inherently profiteering, even if it makes less money, it will still earn 20% or 30% of the profits. The advantages of new drugs with the same target are lower risk and faster capital return, so they have become the first choice of most pharmaceutical companies.

Desferridone began to be ignored, not only because its identity as a rare drug made its expected sales low, but also because its identity as a pure original drug made its risk high and capital return slow.

The former is more difficult to change, but the latter is now changed by Yang Rui.

Seven kinds of active substances through animal experiments reduce the risk of clinical trials. Yang Rui is willing to sign a gambling agreement, which further reduces the risk.

Original drug companies are not afraid of high cost, they are more afraid of risk.

As long as the risk is low, 60 million or 100 million, I don't feel much about them.

Now the cost of new drug development is rising, and the 200 million and 300 million are very common. That's still done at a very high cost. Yang Rui's gambling agreement is actually in line with the expectations of pharmaceutical companies.

However, the gentlemen of the pharmaceutical company are happy, but director Liu is not happy at all.

He gave his bicycle to an employee of jerichon. He got into jerichon's car and asked about their negotiation details.

Yang Rui selectively told him something. Before he talked about the offer of clinical phase II, President Liu sighed a long time

"I remember you asked us before, do you want to make desferridone? That's it, deferonone. " President Liu asked regretfully.

Yang Rui nodded: "if you refuse, I will cooperate with Huarui laboratory."

"That is to say, if we had agreed at that time, we would have recovered tens of millions of dollars now?"

"Not necessarily. If I sign this agreement, I may not get a dime, but I may take back tens of millions." It's not necessary to sign a gambling agreement. If Peking University owns the patent of deferonone, the most likely way to sign a contract is to directly authorize it by milestone, and there is a chance to recover 20 million, 30 million, or 40 million, 50 million.

President Liu selectively ignored the part of "not getting a dime". He looked at Yang Rui and said, "PCR, we missed it. Desferridone, too. Yang Rui, you can't try your best to sell good things to Huarui."

Yang Rui shrugged his shoulders and said, "I've asked you about both. You don't want me to send Hua Rui."

"You should have advised us more."

"No matter what I say, the funds are real. It's the funds that dissuade you, right?" Yang Rui said: "at the beginning, PCR cost more than one million US dollars. Now it costs millions of US dollars. That's good luck. If it's not good luck, it costs twenty or thirty million US dollars. Peking University can't afford so much money. I'm boasting so much that the project still has to go yellow."

When he was doing PCR, Yang Rui made a false inquiry. If Peking University really wanted it, he would rather drop out than give it. However, the situation of deferonone is different. If Peking University is really willing to take the risk, Yang Rui is willing to take deferonone out. Because the risk is real, before Yang Rui did it, he was not sure how long he would be able to do it, let alone the results and costs. Maybe it will take a year or two, tens of millions of dollars, to get to the end.

If Peking University can make a full investment, it will naturally provide more and more professional pharmaceutical experts. Yang Rui can not only save time to do other things, but also gain a lot of reputation and honor from deferoxane.

Of course, now that things are made, it's useless for Dean Liu to say anything else.

President Liu himself knew this, shook his head, said: "no, you have a new project, you have to give us a good talk."

"That's for sure." Yang Rui really said a word, immediately asked: "more funds to the project, you can stand?"

"It depends on how much." When it comes to funding, President Liu is still a bit empty, turned around and said: "talk about ferroketone first."

"Didn't you just say that?"

"You just talked about the negotiation, the cause and effect, and the specific research.""Ah... How long does that take?"

"No hurry, let's go back and talk slowly." President Liu said, patting the back of the driver's chair in front of him and saying, "go to Peking University."

"Now?" Yang Rui looks at his watch. It's past 8 pm.

President Liu said unambiguously: "go, academician Cai, they are all waiting. New drug research has just started in China. "

With that, President Liu swept Yang Rui up and down with his eyes.

Yang Rui was swept all over uncomfortable, asked: "we can't all wait in the office, when I call you, all work."

"Off work. Everyone is gathering at academician Cai's house. My sister-in-law cooks. We can drive faster and mix some soup. " President Liu urged the driver.