After staying at a motel at the outskirts, Bruce Banner and Betty Ross is traveling towards Manhattan

to meet Bruce's internet friend 'Mr Blue' who claim to have made an antidote to prevent Bruce's transformation into Hulk ever again. Inside the truck as Betty is driving, Bruce glanced outside of the window and started thinking on how he ended becoming the Hulk and how much he has suffer to reach this moment in time.

All of this started at Culver University in Virginia, where General Thunderbolt Ross requested Bruce and his daughter Betty to run an experiment which Ross claim to be able to make humans immune to gamma radiation. In actual fact, Ross lied to them in order to recreate the super soldier program that created Captain America.

The experiment fail and it cause Bruce to be exposed to gamma radiation turning him into Hulk

for brief periods of time. The Hulk destroyed the lab and surrounding area, killing several people inside and injuring both General Ross and Betty. Bruce soon becomes a fugitive from the U.S. military and Ross in particular, who wants to weaponize the Hulk.

Whenever Bruce heart rate rises above 200 beats per minute or if he is subjected to emotional stress will turn him into the Hulk without Bruce being able to control his action. As Bruce Banner, he is approximately 5'9" tall and weighs 128 lbs but when transformed into the Hulk, he stand between 7–8 feet tall and weigh up to 1,400 lbs.

Hulk's abilities consist of invulnerability, regenerative healing factor, superhuman strength, superhuman stamina and superhuman durability. Other than that, Hulk's level of strength is proportionate to his level of anger.

As a fugitive running away from General Ross for 5 years, Bruce end up in Brazil working in a soft drink factory while attempting to find a cure for himself with the help 'Mr Blue' an internet friend. To help control his emotion, Bruce studied martial arts and meditative breathing techniques.

General Ross located Bruce due to an accident in the factory where a drop of Bruce's blood find its way into a bottle and eventually drank by a consumer. General Ross send a team of soldiers lead by special operations expert Emil Blonsky to capture him but failed. Bruce transform into the Hulk and a huge battle occurred in the factory before Hulk evaded capture.

Bruce ended up in Guatemala and he traveled back United States to return to Culver University to find data of the original experiment to help his research. As he return to Culver University, he saw Betty there working at Culver University and she is currently dating psychologist Leonard Samson. Needing a way to sneak into Culver University, Bruce work as a delivery boy for his old friend Stanley a pizzeria owner.

....

After General Ross explains how Banner became the Hulk, Blonsky seeking both revenge and power volunteers as a test subject in order to capture Bruce. Blonsky receives a small sample of the serum taken from Culver university that help enhanced his speed, strength, agility, and healing, but it also slowly begins to deform his skeleton and impair his judgement.

....

Blonsky lead the assault team at Culver University to capture Bruce but Blonsky judgement started deteriorating making Blonsky wanting to compete one on one with Hulk. As Bruce was cornered by the military, Bruce is forced to transform into the Hulk as he was attacked with sleeping gas.

Blonsky's increased strength, speed and agility allowed him to avoid all Hulk's attacks but Blonsky was not able to damage Hulk with any of his weapons. The ensuing battle outside the university proof to be futile for the General Ross's military as Hulk destroyed all the military vehicles causing them to retreat back to safety.

Blonsky due to his faltering sanity confronted Hulk directly and taunted Hulk to fight with him while the same time mocking Hulk. In anger, Hulk delivered a kick towards Blonsky's body crushing most of his bones.

Since Betty was knocked unconscious due to the attacks made by the military, Hulk escape with her to a cave in Smoky Mountain National Forest before eventually calming down and becomes human again. Eventually they stayed at the motel to recuperate before ending up in their current situation traveling towards Manhattan in a truck.

As Betty was driving she asked "Bruce, what is it like? When it happen. What you have experience?"

Looking back at her, Bruce replied " You remember those experiments we volunteered for in Harvard, they induce us to have hallucinations, it is a lot like that but it is a thousand times amplified. It is like someone poured a liter of acid in my brain".

Betty with curiosity asked "Do you remember anything?".

"Just fragments, images, there is too much noise, I can't derive anything to make anything out of it" Bruce replied as he think deeply.

Betty try to reassure him "But then it is still you inside it" which Bruce quickly dismiss "No it is not"

"I don't know but in the cave, it really felt that it know me. Maybe your mind is in there but it is just overcharged that you can't process what is ha....." Betty contemplate.

Bruce interrupted her and with conviction said "I don't want to control it. I want to get rid of it" ending the conversation as he stared out of the truck's window deep in thought.

Betty stared at Bruce out of concern before focus her attention back on the road with the determination to help him with all her power and get their life back together.

...

Military Hospital

Blonsky who was presumed to be dead by everyone due to his injuries is found to be alive but all his bones is crushed. Overnight Blonsky completely healed from all his injuries due to the serum he has taken which deeply surprise everyone due to the recovery speed and that they presume that he won't survive.

As Blonsky saw General Ross entered the room , he called out "Sir".

With amazement General Ross walk slowly towards Blonsky in admiration of the serum's capability and gently examine Blonsky's body . Thinking to himself that once he get Bruce, he will be able to recreate the perfect super soldier serum for the military.

General Ross with a smirk to himself before saying "It is good to see you back on your feet soldier".

"Thank you sir!" Blosky replied as he stared at General Ross

"How do you feel?" General Ross asked Blosky with a smile on his face.

"Pissed off and ready for round three!" Blonky replied with all intention of seeking revenge and showing that he is better than Hulk.

With that Blonsky underwent another procedure to inject the same serum into his spine which further deform his skeleton and impair his judgement even further. The only thing he feel when undergoing the procedure is that he feel very powerful like a monster and he that like the feeling of having immeasurable power within him. Blonsky grin to himself feeling the huge excitement in face hulk again.

.....

Bruce and Betty travel toward Manhattan, New York was not smooth as they wanted. They faced road blocks so they ended up using a boat to enter New York City. Using the subway is not an option as they are worried that Bruce will turn into Hulk and injure a lot of people since it is in the most aggressive city in the world. There is a possibility someone will piss him off.

Taxi driver drive to aggressive and dangerous in New York City so they opted to walk all the way to meet up 'Mr Blue' otherwise known as Samuel Sterns at Grayburn College. Doctor Samuel Sterns is a cellular biologist and Grayburn College professor who is able to create a temporary antidote for Banner's condition.

Dr Sterns has developed a possible antidote that may reverse Banner's transformations after their occurrence but might not prevent future ones. Dr Stern warned Bruce and Betty of the the problem that might occur when injecting the antidote is that an overdose will kill Bruce if they are not careful.

Despite all the risks, Bruce agrees to test Sterns' antidote to determine whether the antidote work or not. In Dr Sterns's laboratory and is restrained to the chair before being shocked into transforming into Hulk with electricity and as Bruce's Blood is mixed with the antidote in the dialyses and injected back into his body in order to revert Bruce back to normal.

While all this is happening, as the General Ross, the soldiers, Dr Stern and Betty is distracted by the transformation that is happening to Bruce. A figure in Black and Blue costume (Nightwing) stealthy entered one of the laboratory room stealing a sample of Bruce's synthesized blood and blood sample before quickly exiting the building without been notice by anyone.