Chapter 608

For Jean Agust's work, the stone bear has no other idea but to be satisfied.

This is penicillin.

In this era, this thing is the magic medicine to cure diseases and save people! It can definitely exist side by side with vaccination.

You should know that in the original historical time and space, penicillin was known as one of the three major inventions in World War II, which coexisted with mushroom bomb and radar.

The plan of mass production of penicillin in the United States during World War II is second only to Manhattan plan.

If there is any regret now, it is the production of penicillin. However, this is not a problem, as long as we find a way to purify penicillin, the increase of production is only a matter of time.

"Let's see, how's penicillin tested on animals?" Asked the stone bear.

This made Agust's excited face suddenly collapse. "Chief, before the purification of penicillin, we have used penicillin culture medium to do many experiments on animals, but the effect is not very ideal. I think it has a direct relationship with the low dose of penicillin in the culture medium. However, I think that if the use of purified penicillin to increase the dose of experiments, I think the effect will be better, but also need to test the proportion of penicillin dose

This made the stone bear sigh in his heart.

Sure enough, penicillin is not so easy to get.

Now we have found a way to purify penicillin, and we have also successfully purified penicillin, but we really can't do it with such a small amount.

In fact, in the original historical time and space, when Fleming discovered penicillin, there were only two poor units of penicillin in a liter of penicillin medium at that time. According to this concentration, if the dose of penicillin injected intramuscularly is estimated to be 600000-800000 units a day, the water from a 25m short track swimming pool needs to be poured into the human body to achieve therapeutic effect.

This is obviously impossible.

But in order for penicillin to work, the dosage must be increased.

Although the culture medium used by Agust has been replaced by corn steep liquor, the dose of penicillin in the culture medium has been greatly increased, but it still can not meet the standard of clinical trials.

At that time, Fleming was trapped in the inability to purify penicillin and to realize the transformation of penicillin from 0 to n.

Later, even after Australian pathologist Howard Walter Florey and German bacteriologist Ernst chann found out how to purify penicillin, they were unable to give full play to the great effect of penicillin at first because of its yield.

When Flory and chann found out how to purify penicillin at Oxford University, they began to employ many local girls to cultivate penicillin in all kinds of bottles and cans that could be found at Oxford University. It is said that he turned Oxford University into a mould factory at that time.

But even so, the production of penicillin still can not reach the point of clinical application.

But Flori is a real genius. He is not only proficient in pharmacology, but also an outstanding organizer.

Flory was very clear that with the strength of himself and chann alone, he could not develop penicillin that could be used in clinical practice, so he asked more experts to study how to increase the production of penicillin.

One of the people Flory got was Norman hitley. So Hitler developed an aqueous solution of penicillin, and adjusted the pH of the solution, which made penicillin can be used in animals and human body.

However, penicillin obtained by this conventional method is still very few, or even not enough to treat a patient with bacterial infection. So Flori began to seek help from pharmaceutical companies. He contacted the British pharmaceutical companies first, but all the forces together were not enough to solve the problem.

So Flory and Hitler went to the United States for help, and they found the Rockefeller Foundation.

Rockefeller Foundation has money. With money, Flori made a breakthrough in his subsequent research.

He used corn steep liquor instead of sucrose as culture medium, which could increase the yield 20 times.

But the output has increased, and penicillin strains are not enough.

In this world, there are many kinds of mold, some easy to produce penicillin, some do not. In order to find a new strain, Flory sent out all the people in the laboratory. As a result, a researcher named Mary hunt found a hairy melon on the fruit stand and found that the yellow green mold on it had grown to the deep layer, so he brought it back.

This kind of yellow green mold can extract penicillin very well, so after using the new strain and corn steep liquor, the yield of penicillin increased by 20000 times!

However, even so, the production of penicillin was still insufficient. Later, several major pharmaceutical giants in the United States joined in, and thousands of engineers worked together. Finally, the concentration of penicillin was increased by nearly 100 times, which met the requirements of industrial production.

Therefore, the successful purification of penicillin is far from enough, how to increase the concentration of penicillin and penicillin production, is the key.

But as soon as the stone bear thought of this, Agust said: "chief, we have found a way to cultivate penicillin in the melon you said. The melon you said is really a good thing to cultivate penicillin. Now we don't have to worry about the source of the strain."

After a pause, Agust continued: "and we also use corn steep liquor as the culture medium according to the method you said at the beginning. The effect of this culture medium is very good, and the cost is very low. We are fully qualified for large-scale cultivation of penicillin strains. Now that the problem of strains and culture medium has been basically solved, the next step is to figure out how to continue to increase the concentration of penicillin strains. "

Shi Xiong nodded. He had told Agust all the methods he knew about how to increase penicillin production. At least now Agust's production of purified penicillin has reached the threshold of industrial mass production. Next, as long as the concentration of penicillin strain is increased, industrial production can be carried out.

But this process should take a long time. After all, the engineers of those pharmaceutical giants in the United States in the original historical time and space have no idea how to continue to improve the concentration of strains, so they can only rely on Agust's scientific research team to study little by little.

Thinking of this, Shi Xiong nodded and said, "let's say that although we have made breakthrough progress, we still don't have the conditions for industrial mass production. Therefore, how to further improve the concentration of penicillin strain is your main goal in the next step, and your task is still a long way to go. Well, if you have any ideas, you can do it with confidence and boldness. Don't worry about what you need. I will try our best to satisfy you. "

Agust nodded heavily.