Chapter 538

High precision laser processing technology has achieved success.

Regardless of the great strategic significance, in terms of robotics alone, the bottleneck of reducer no longer exists.

Next, Luli plans to overcome another difficulty servo motor.

However Things are hard to predict.

Just when Luli was ready to put into the research of servo motor, he unexpectedly learned a news, which made Luli have to change his research direction.

That evening, Lu Li returned to Fudan dormitory and had dinner with Liu Qin.

"Lu Li, do you remember Wang Yan?"

Liu Qin gives Lu Li a chopstick dish and looks up at Lu Li.

"Wang Yan?"

Lu Li thought a little, strong memory, immediately let Lu Li from the depths of memory to find out the memory.

Wang Yan, Lu Li's high school classmate.

At Yucheng No.1 middle school, Wang Yan was Liu Qin's deskmate.

"Wang Yan, old classmate!"

Lu Li smiles and says to Liu Qin, "at the beginning, when I was in Yucheng No.1 middle school, Wang Yan was at the same table with you! Why did you suddenly mention Wang Yan today? "

"Wang Yan..."

Liu Qin sighed, "she's sick, incurable! This morning, she called me and cried. I don't feel very well, either

"Sick? What's wrong? "

Lu Li put down his chopsticks and asked Liu Qin.

"AIDS!"

Liu Qin sighed and shook his head, "she found a boyfriend, the result..."

"So it is."

Lu Li also sighed and said to Liu Qin, "Wang Yan called you to ask me for help, right?"

It's not hard to guess.

Lu Li is one of the top geneticists in the world. He has also made great achievements in cancer research in the field of medicine.

If anyone has the possibility to conquer AIDS, maybe only Luli can do it.

Wang Yan finds Liu Qin and wants to ask Lu Li for help, which is human nature.

"Wang Yan must have meant to ask you for help."

Liu Qin nodded and said to Lu Li, "Lu Li, Wang Yan Very poor, if you can help, you help her! What's more, tackling AIDS is also a major scientific research achievement! "

"You have so much faith in me?"

Lu Li laughed, "AIDS is one of the five most incurable diseases in the world. Do you think I can find a cure for AIDS in a short time? "

"I must have faith in you!"

Liu Qin said with a smile, "you are the top genetic scientist in the world. If you can't do it, no one can do it. "

"Ha ha! I love to hear that

Lu Li laughed, "OK! I put the project on the hand first, turn to study the treatment plan of AIDS

"Thank you! Thank you for Wang Yan! "

Liu Qin's face is full of joy. He quickly takes out the phone and dials Wang Yan. After getting through, Liu Qin said to Wang Yan, "Wang Yan, I told Lu Li. He'll find a way to help you

"Thank you On the phone, Wang Yan was sobbing.

……

The next day, Lu Li came to the laboratory of Fudan medical college.

In the laboratory, wenwanmeizi and other graduate students are still doing the human gene testing project, which is not far away from the results.

Lu Li did not disturb them, turned to another laboratory, ready to study HIV.

HIV, a retrovirus, mainly invades T cells in the body's immune system, thus destroying the body's immune system.

This is a typical pattern of virus invasion.

HIV invades T cells, and then transcribes, replicates and generates countless HIV in T cells, so as to spread in a large area, kill T cells in a large area and completely destroy the human immune system.

At present, according to the WHO report, there are nearly 40 million AIDS patients in the world, with 2.7 million new infections each year, and 2 million people die of AIDS each year, with an average of tens of thousands of people infected with AIDS every day.

In China, there are nearly one million AIDS patients, covering all provinces and autonomous regions.

AIDS is very harmful. So far, there is no cure.

This time, because of Wang Yan's affairs, Lu Li devoted himself to the treatment and research of AIDS.

In fact, this is not only for Wang Yan, but also a major scientific research benefiting the whole world.

In the lab.

Lu Li sat in front of the test bench and carefully observed the process of HIV invading T cells through an electron microscope.

On the screen, HIV invades the nucleus and breaks down into RNA genes to transcribe information.

Immediately, the HIV gene transcription information, soon combined with the DNA molecular chain in T cells. By deceiving gene transcription mechanism, DNA transcription mechanism generates HIV DNA molecule according to transcription information.Non stop transcription, non-stop generation of HIV DNA molecules. Until the whole T cell is full of HIV.

By this time, T cells are dead and all the nutrients are used to produce HIV.

Next, thousands of HIV, oozing from the dead T cells, continue to spread, crazy invasion of other T cells.

This is the mechanism of HIV infection.

, as like as two peas, all the viruses are infected by the same genetic information, which is combined with DNA, and constantly replicating, generating new viruses and invading other cells.

For T cells, Luli has been studied deeply.

When we first studied cancer treatment, car-t anticancer technology developed by Luli used the immune function of T cells to kill cancer cells.

Now, in AIDS, the weapon used by Luli has become the target of virus attack.

To treat AIDS, Lu Li still started from the aspect of genetics.

In today's world, all AIDS treatment programs are not successful, at least can not be completely cured.

From the perspective of genetics, Lu Li has come up with a solution to HIV, and it is also a method that has existed in nature for a long time.

In nature, a war that has lasted for hundreds of millions of years is breaking out all the time, right around us.

This is the war between bacteria and viruses.

Virus invading bacteria is no different from invading human cells. It also combines virus gene transcriptional information with bacterial DNA molecules, makes different transcriptions and keeps replicating.

In the hundreds of millions of years of war between viruses and bacteria, bacteria have evolved a defense mechanism to fight against viruses.

This gene sequence, called CRISPR, is a repeated sequence in the genome of prokaryotes. It is an immune weapon produced by the struggle between bacteria and viruses in the history of life evolution.

In short, bacteria evolved crispr-cas9 system in order to eliminate the invasive genes of virus. Using this system, bacteria can quietly remove virus genes from their genomes, which is the unique immune system of bacteria.

In fact, the gene editing technology in the world today is based on the crispr-cas9 system.

Now, Luli's idea is to arm T cells with crispr-cas9 system.

Once HIV invades T cells, crispr-cas9 system will cut off the genetic information of HIV, so as to prevent HIV infection.

If the technology is successful, a vaccine against HIV infection can be produced.

Of course, for patients who have been infected with HIV, the technology still has enough therapeutic effect.

T cells in the body's immune system can constantly replicate and proliferate. If all the newly born T cells have the ability to fight HIV, then Even if HIV kills all the original T cells, it cannot invade the newly born T cells.

In this way, HIV cannot destroy the human immune system. The remaining HIV will also continue to invade new T cells because of the virus, constantly being cut gene information by crispr-cas9 system, and eventually all die.

Theoretically, this idea can be realized.

Now it's up to us to see if we can successfully complete the experiment and equip crispr-cas9 system into T cells.

"Open the virtual lab!"

Lu Li's mind moved and directly opened the virtual laboratory, ready to do research in the virtual laboratory.

"A virtual AIDS patient."

Lu Li is going to do the human gene experiment directly. This kind of experiment is not easy to do in reality, it is very convenient to do in the virtual laboratory.

After a virtual AIDS patient, Lu Li picked up the needle and took out a hematopoietic stem cell sample from the patient's spinal cord.

T cells in the human immune system are transformed by hematopoietic stem cells under the induction of thymic hormone.

Lu Li's current research is to equip crispr-cas9 system when hematopoietic stem cells transform into T cells, so that the newly generated T cells can have cellular immune function.

It is not difficult to equip cells with crispr-cas9 system.

In gene editing, crispr-cas9 splicing protein must be injected into the cells to be edited.

The real difficulty lies in how to make the hematopoietic stem cells produced in the spinal cord automatically generate immune T cells according to the new template in the process of transforming them into T cells.

This involves RNA gene transcription information.

Luli must also express armed T cell genes in the form of RNA gene transcription information, so that hematopoietic stem cells can replicate according to this new template.Fortunately, with Lu Li's current knowledge of genetics, it is not difficult to achieve this.

Next, Lu Li extracts the gene information target of AIDS, adds it to the gene target of crispr-cas9, and injects it into T cells to bind with T cell DNA molecular chain, and then injects transcriptase to generate new gene transcription information.

The transcriptional information of newly generated genes was extracted and injected into hematopoietic stem cells to bind with DNA molecular chain of hematopoietic stem cells.

So In hematopoietic stem cells, according to the new gene transcription information, they begin to generate new DNA molecular chains and new immune T cells.

At this point, 90% of the experimental process has been completed, and the next step is to see the real therapeutic effect.

Luli cultivated hundreds of millions of prepared hematopoietic stem cells, reinjected them into patients, and transformed them into new armed T cells through thymus.

After waiting for a few hours, Lu Li extracted lymph from the patient's body for testing.

It turns out that A large number of newly generated T cells with crispr-cas9 system have appeared.

In these T cells equipped with crispr-cas9 system, the virus gene information of HIV invasion was all targeted by crispr-cas9 system target information, which directly shortened the HIV gene information and successfully killed an HIV.

The immune system is constantly generating new T cells. These new T cells, all equipped with crispr-cas9 system, can kill the invading HIV.

Wait until the patient's body after a round of replacement of T cells, once HIV invades new T cells, it will be one by one destroyed, eventually completely disappeared.

This process Lasting about one to three months, up to half a year, HIV will be completely killed.

Of course, before the complete cure, HIV in these patients is still highly infectious.

It took two weeks in reality and more than four months in the virtual lab. This virtual AIDS patient, completely cured.

Lu Li has carried out a detailed test on this virtual patient, and HIV has not been found in the patient's body.

The experiment is successful!

Next, Lu Li repeated the gene experiment in reality. Human experiments can't be done in reality.

After repeating the gene experiment in reality, the following time is the time to write the paper.

"An AIDS treatment program based on crispr-cas9 technology."

In this paper, Lu Li wrote out all the theoretical expressions of crispr-cas9 technology, and theoretically demonstrated the feasibility of using crispr-cas9 technology to edit and modify T cells for the treatment of AIDS.

Of course, there is no detailed experimental data or detailed operation steps in this paper for public publication, which is only theoretical demonstration.

Lu Li sent the other article to the Institute of medicine, Chinese Academy of Sciences.

Published papers, contributed to the international authoritative medical journal "Lancet", and also put the papers on the academic network.

So Professor Lu is famous all over the world again.

"I buy it! Professor Lu has developed a treatment plan for AIDS! "

"Does Professor Lu finally remember that he is a medical scientist?"

"The great doctor who conquered cancer conquered AIDS."

"This is a great achievement! Tens of millions of AIDS patients around the world have ushered in their salvation. "

"Is AIDS no longer bothering mankind? That's good news. "

Professor Lu won the Nobel Prize in medicine. No one but him is eligible for the Nobel Prize in medicine. "

"There is one less incurable disease troubling mankind. Even the most demanding people must admit that Professor Lu is the greatest scientist in the world. "

The scientific and medical circles warmly appreciated Lu Li's achievements in conquering AIDS.

Even Foreign media are all advocating it.

Professor Lu has such a high talent in medicine. Of course, he should focus on medical research for the benefit of all mankind. Don't be distracted by other science and technology.

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