Chapter 588： Artemisinin

While Marin was busy planning things in the metropolitan area, Gorard in Panama sent a boat back to Europe to report to Marin that several young men died of malaria due to mosquito bites.

Although, Marin provided Gorard with a lot of mosquito repellent toilet water. However, not everyone applies himself with toilet water every day. Some young men, relying on their youth, are not stable enough. When it was time to apply toilet water, they simply did not apply it because of fear of trouble. So, in the end, some strong guys got malaria after being bitten by mosquitoes, and then died like that.

This incident caused panic among immigrants from Panama. Some people even cried in fear and wanted to go back to Europe. In addition to slamming, Gorard has no other way. Right now, because of the panic in the hearts of the white immigrants, even the mood of driving the black people to cut the trees is gone, causing the problem of open roads in Panama to stop. Therefore, Gorard sent people back to China for help. After all, he heard that Marin had Morigen and Battle doctors next to him, hoping they could give a solution.

But where can Morzhigen and Battle give a solution? Before Cinchona was discovered, malaria was an incurable disease. In China, it is believed that malaria is caused by tropical malaria. Therefore, the ancient Chinese people always regarded the land of Lingnan as a dangerous place. Many criminal officials were exiled to Lingnan as a serious punishment.

In fact, if ancient China could find an effective treatment for malaria, it would have developed Lingnan on a large scale. Even Vietnam will be the target of the Central Plains dynasty.

The reason why the Central Plains dynasty abandoned Vietnam is because Vietnam is tropical and is prone to malaria. Once malaria is easy to die, the Central Plains people are naturally not happy to be there. In addition, the Vietnamese chiefs also like to pay tribute and hold their thighs, and they are good at racking horses. The Central Plains Dynasty is even more reluctant to conquer Vietnam. Of course, the Vietnamese can't keep up with North Korea when it comes to meeting horses. The stick's ancestors would pat on horses and hug their thighs. Zhu Yuanzhang was pleased and directly listed North Korea as an inexhaustible country. But in fact, North Korea's climate is much better than Vietnam, and there is no malaria, in fact, it is very suitable for living. However, they fared well and sent the Korean women to the Ming Dynasty palace. The emperor fell under the pomegranate skirt. How could he be willing to ask North Korea again? There are even rumors that the birth mother of Ming Chengzhu Zhu Di may be a Korean concubine. Although this statement is not reliable, it is certain that there are Korean concubines in the Ming Dynasty palace. According to records, Yongdi Emperor Zhu Di and his grandson, Xuande Emperor Zhu Zhanji, each received eight Korean concubines ... and they were lucky to solicit others?

Oops, I got off the topic, but, anyway, if ancient China received a magic medicine to treat malaria, it is estimated that it would have conquered Vietnam long ago, and might even conquer Laos, Cambodia and Thailand. But because of the fear of "malaria", it did not continue to expand southward.

However, as a traverser of later generations, Marin knew that ancient China was only one step away from the treatment of malaria ...

Before Marin passed through, he knew that the later Chinese great **** slaughtered, but he discovered artemisinin, which is a more effective curative drug for malaria than cinchona cream.

Because Tu You won the Nobel Prize in Medicine, so in the past life of Marin, the media gave a lot of reports, making Marin, a liberal arts student, also had a strong interest in artemisinin, and consulted relevant information.

The reason why ancient China is only one step away from the treatment of malaria is due to the particularity of artemisinin.

Artemisinin, as the name suggests, is naturally extracted from Artemisia annua. In ancient China, Artemisia annua was listed as an herbal medicine very early. It should be said that malaria can be cured early.

But this is not the case. This is because the important thing is that it usually takes a long time to cook on the fire. The problem lies in this medicine ...

Why? Artemisinin is a substance that cannot be heated. When heated, it can be easily converted into other substances and lose its ability to treat malaria. Traditional Chinese medicine takes a long time to be cooked in a medicine pot. Once the artemisia annua is cooked, the natural efficacy disappears or is greatly reduced, making it impossible to treat malaria. Therefore, ancient China has never known that Artemisia annua can treat malaria.

Of course, no one does not know this. There were some powerful doctors in the Ming dynasty who knew that Artemisia annua was directly smashed and taken to treat malaria. However, this method has not spread widely. And traditional Chinese medicine naturally admires medicine, so people cannot overcome malaria.

After searching for related information, Marlin later learned that the extraction of artemisinin, the general temperature does not exceed 70 degrees, to avoid the loss of conversion of drug efficacy.

Moreover, it is very important that artemisinin is insoluble in water. This makes it extremely difficult to extract.

If artemisinin is soluble in water, it will be simple. Shred the Artemisia annua directly and soak it in water. Artemisinin can be obtained by air-drying without heating.

The problem is, artemisinin is insoluble in water ...

During the research and development, Tuyoyo heard that the ancients had treated malaria with raw artemisia annua, so they tried to extract this substance. However, it has not been successful.

Until one day, she suddenly felt that this substance is insoluble in water? So, she changed to dip the artemisia annua with ether, and she extracted artemisinin. Later, a production method for extracting artemisinin by gasoline immersion was also developed ...

But Marin knew that artemisinin is not only soluble in ether and gasoline, but also alcohol ...

Because alcohol and ether are similar substances, the properties are similar. Of course, according to the summary of future generations, the extraction of artemisinin with alcohol may not be as effective as ether and gasoline, but it can also extract artemisinin. Because artemisinin is soluble in alcohol.

As it happens, Marin now owns a lot of grain-brewed wine, and also extracts and produces a lot of medical alcohol. Moreover, as a liberal arts student, Marin does not know how to produce ether. Without oil, he could not make gasoline. Therefore, extracting artemisinin with alcohol has become Marin's only choice.

As it happens, there was very little artemisia annua in the herbal seeds brought by Mozhigen and Battle. Although the quality of Artemisia annua in northern grasslands may be poor, far less than that of Artemisinin in Youyang Artemisia annua, it can also be used to extract artemisinin.

Moreover, now Marin's men have planted hundreds of acres of artemisia annua, in a remote manor belonging to Marin near Aurich.

Gorard didn't write, Marin almost forgot those artemisia annua. But now, Marin thinks about it-it seems that he can use those artemisia annua to extract artemisinin ...

So, Marin sent people to the manor and brought a large amount of Artemisia annua ...

At the same time, Marin went to the winery and got a large amount of medical alcohol and began to extract artemisinin ...

Marin first sent people to chop up the artemisia annua, then put it in medical alcohol and soak it, and cover it (alcohol is volatile).

After a long time passed, Marin asked the person to open the lid and use gauze to filter out the chopped grass residues of artemisia annua, to obtain an alcohol solution in which artemisinin was dissolved.

Then, in order not to waste alcohol, Marin asked the cauldron for steaming wine, and began to heat the solution intermittently with a small fire, trying to make the solution temperature not exceed 70 degrees.

Then, the alcohol dripped little by little through the cooling tube and was recovered into a specific container, ready to be reused ...

When there was not much alcohol, Marin took the point directly into the air to dry it. Then, I got artemisinin with very different colors ...

This is because Marin did not use activated carbon to absorb some pigments and other impurities in the solution, which made the extracted artemisinin look unattractive.

But Marin doesn't care, as long as it works, let him sell it?

However, the acquisition rate of artemisinin is really touching-it is less than one thousandth ...

Although there is a problem with the extraction process, which leads to incomplete extraction, it is important to know that the artemisinin content of Artemisia annua in Youyang exceeds eight thousandths. Therefore, the artemisinin content of Youyang Artemisia annua L. is several times that of the common artemisia annua brought by Mozhigen and Battelle ... This made Marin have a strong desire to find the seeds of Youyang Artemisia annua ...

But in any case, Marin still got a lot of artemisinin. A total of 10,000 pounds of artemisinin hay was shipped and nearly 10 pounds of artemisinin was extracted.

You know ~ www.novelhall.com ~ there are tens of thousands of pounds of artemisia annua in the manor. If you use them to extract, you can extract dozens of pounds of artemisinin. For treating a malaria patient, the amount of artemisinin is only 6 to 12 grams. Even according to the maximum 12 grams, 10 pounds of artemisinin can cure 378 patients. After extracting dozens of pounds of artemisinin, it is enough to cure more than a thousand malaria patients ...

After getting the artemisinin, Marin was overjoyed and ordered people to make a lot of oil paper bags to pack the artemisinin. Moreover, Marin made a small packaging oil paper bag with a weight of 12 grams for easy use. If a strong man has malaria and is very serious, he takes the whole package of 12 grams of artemisinin and takes it. If the elderly and children are so weak, pouring out a part of the bag is enough to cure. In this way, it is also greatly convenient for doctors to use.

The 10 pounds of artemisinin in Marin's hands were put into 378 small oil paper bags, which were sealed and sealed to prevent moisture damage. Then, he planned to send the ship to Gorard. Of course, Tala on the Cuban island will also have to send some.

The other artemisinin in the manor, the extracted artemisinin, Marin intends to distribute it to the people of the ocean-going fleet to deal with emergencies along the way. Moreover, artemisinin can not only treat malaria, but also treat malaria, such as kala-azar and lupus erythematosus, and is a magic drug. Of course, because it is rare and precious, it is best to deal with fatal malaria and other serious diseases. It's a waste to treat minor diseases ...