Chapter 1777： : Where is the core technology?

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This discovery almost made the entire institute boil!

The discovery of this polymerase seems to directly verify the common ground between Parkinson and Alzheimer in neurodegenerative diseases!

However, this is not the key.

The most important thing is that Parkinson's attack finally has a breakthrough!

Chen Cang himself did not expect that the temptation of enzymes is so powerful!

The polymerase that was the culprit was discovered directly.

After the discovery of polymerase, all departments began clinical research and various experimental work!

The progress of the experiment can almost be said to have advanced by leaps and bounds!

Everyone is immersed in this breakthrough-like progress!

Tedanis now does not regret joining Chen Cang's camp at all.

He believes that even Considine can't do this, and can isolate poly ADP-ribose polymerase-1!

This kind of polymerase belongs to ribose polymerase, which exists in the mitochondria and ribose of cells, and the separation is extremely difficult!

For a while, the news that Professor Chen isolated this polymerase spread throughout the institute!

Everyone was shocked!

Professor Chen has such a talent in scientific research?

Creatively invented a technique called "foam separation".

For a while, Chen Cang's reputation boiled again.

However, the most important thing is not Chen Cang's reputation.

It was Boss Chen’s innovative discovery, direct extraction of poly-ADP-ribose polymerase-1!

And the research of this enzyme on Parkinson is also increasing day by day!

Soon, Taidanis led the team to announce that the main function of this polymerase is actually to be widely present in the nucleus and repair DNA!

Under normal conditions, after the polymerase detects DNA damage, it will be activated and then repaired!

However, when the case environment causes the DNA to be unable to be repaired, this polymerase will be overactivated!

As a result, it leads to degenerative diseases of the nervous system, which intensifies the growth of folded alpha-synuclein, and again induces Lewy bodies...A series of complex processes lead to aggravation of Parkinson's!

This discovery of Taidanis made Yang Lan's eyes bright.

Qi Kai and Yang Lan quickly started animal experiments!

Animal experiments are a link to the correct answer!

The theoretical basis has made this experiment more and more anticipated.

Obviously, once a conclusion is reached, it will shock the world.

In the process of research!

When Yang Lan and Qi Kai conducted animal experiments on Parkinson's rats.

Discovered more and more terrible to even shocking problems!

The human body has a rich and complete feedback system.

And Parkinson's special state makes the adjustment of this polymerase lose the opportunity for feedback!

In the same way, the presence of this polymerase also aggravated the increase of folded alpha-synuclein in patients with Parkinson's, which further aggravated the condition of Parkinson's.

What a process has this formed!

Vicious circle!

That's right!

Parkinson let the polymerase lose its limits.

Polymerase increased the folding of α-synuclein and increased Parkinson's!

In this way, it seems that a closed loop is formed.

If one link is not broken, the cycle will become more serious.

one week later!

When Chen Cang was in the hospital, Qi Kai called Chen Cang directly into the institute!

Pass a copy to Chen Cang!

"Professor Chen, look at this thing!"

Chen Cang was stunned for a moment. After he opened it, he was stunned when he saw the question!

"The neurotoxicity of alpha-synuclein!"

Chen Cang quickly began to look at it.

From this look, Chen Cang couldn't help it!

Because Taidanis and their research found that folded pathological α-synuclein aggregates can spread between brain neurons!

Moreover, this pathological α-synuclein will become a seed, inducing normal α-synuclein, leading to degenerative diseases of the nervous system!

After seeing this scene, Chen Cang himself was stunned!

Qi Kai couldn't help but said: "Now I finally explain why Parkinson's rats have an increased mortality rate!"

"Because folding alpha-synuclein is contagious!"

"And this polymerase is the most critical intermediate product!"

Taidanis was a little excited and said: "As long as this polymerase is solved and reasonably inhibited, the onset of Parkinson's can be directly delayed!"

Zhang Mu shook his head: "Not only that!"

"The most important thing about Parkinson's is not post-treatment, but early prevention!"

After hearing the sound, everyone suddenly thought of it carefully!

Zhang Mu continued: "This is a vicious circle!"

"As long as there is a folded pathological α-synuclein, a variety of polymerases will definitely breed, and similarly, polymerase aggravates the folded α-synuclein!"

"In this way, the most important thing is how to find the folded α-synuclein as early as possible, and to intervene with surgery and drugs in time!"

After Zhang Mu said this, everyone suddenly became excited.

Yes indeed!

In this way, it seems that they have found a good way to attack Parkinson as soon as possible.

Treatment is no longer the goal!

It's about discovering and intervening as soon as possible!

"How to check the folded alpha-synuclein in the human body?"

"Yes, how can we find out that people have Parkinson?"

indeed!

Parkinson's disease itself is a symptomatic disease Only when it has manifestations can it be discovered.

Can't everyone go to the census for an alpha-synuclein?

This is definitely not realistic!

Couldn't Parkinson's prevent it?

Thinking of this, everyone couldn't help sighing.

What a pity.

Finally, there was such a breakthrough.

If it can be detected in advance, the patient will save a lot of trouble.

How can we find out in advance?

At this moment, Chen Cang's eyes suddenly lit up.

He thought of a big baby!

The new technology I once sold to Google is the new technology that earned Chen Cang $1 billion: "Brain stereotactic technology!"

This new type of cranial stereotactic technology has a special ability: DTI technology!

That is, MRI diffusion Zhang Liang imaging!

It can realize the integrity and connectivity of tissue structure in vivo observation, which is conducive to the judgment of the degree and scope of damage to the white matter fiber bundles of various diseases.

At the same time, it can also respond to subtle changes in the brain of patients with mental illness. Not only that, DTI technology can also display the direction of nerve conduction bundles in the white matter of the brain, and achieve fine imaging of human central nerve fibers.

Under the guidance of DTI technology, the individual differentiation of Parkinson's disease patients can be accurately displayed and positioned, and at the same time can be fused to perform three-dimensional image reconstruction surgery, guiding doctors to perform precise and efficient surgery.

Chen Cang really didn't expect it!

After going around such a big circle.

The core technology is still in my own hands!

...

ps: There are too many materials to be checked. I am helpless and can't write nonsense. This means that every knowledge point needs to be taken seriously.

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