Chapter 1534

"The price of sildenafil in North America is $7. After taking out the cost, we can get a gross profit of about five yuan per grain. This is mainly because greenstone corner bears a lot of costs in the early stage. If they want to win the global sales agent of sildenafil, they are willing to bear more..." Yang Rui, holding the report in his hand, did not open it, but repeated it to Director Hu.

Director Hu is the director of the office of chemical and pharmaceutical revitalization, which can be regarded as a competent unit of Huarui.

Of course, Yang Rui can also report to the food and Drug Administration and other departments of the Ministry of health, but it is unnecessary and people are embarrassed to listen.

Director Hu listened very seriously.

Before Yang Rui, there was really no domestic experience in what happened to new drugs.

Although there are so many drugs approved by the state every year, except for generic drugs, the rest are proprietary Chinese medicines. Chinese patent medicine can only rely on the domestic to make money. What it makes is the most boring money.

In the 1960s and 1970s, countries still exported proprietary Chinese medicines to Southeast Asia, Hong Kong and Macao, but after the 1980s, there were few. The main reason is the influence of many cultural factors, including the influence of FDA.

Before the FDA, the quality of drugs in Europe and the United States was not very good. It was not common to eat dead people, but it was common to eat disabled people, and there were not many diseases that could be treated. Many common diseases were powerless, especially the incurable diseases such as cancer. Taking western medicine and traditional Chinese medicine, the survival time was almost the same. Basically, they all depended on personal physique and spirit.

But after the 1980s, the level of Western medicine in common diseases has obviously reached a higher level. From the perspective of scientific research, it is the generation of scholars who grew up after World War II, especially those who grew up in the era of genetics, whose research on biological technology has finally begun to be applied in the field of people's livelihood. For example, although darbeko's cancer eradication plan in the 1970s was declared a failure, one billion US dollars was not a pure waste. The research results produced by the money finally came out one after another from the 1980s to the 1990s.

With such a scientific research foundation, western strong politics has room to play.

By about 90 years, Southeast Asian countries have established the corresponding drug review mechanism, so it is difficult to realize the traditional Chinese medicine play.

For leaders like Hu Chi, he hates and fears words like FDA and Western medicine.

This kind of feeling is a bit like Chinese football facing the five leagues and the world cup. On the one hand, he is eager to enter the game. On the other hand, it is not himself who decides to enter the game. In addition to trying his best to understand the situation and issue some useless orders, all he had to do was to publicize the origin of football from Cuju. During the Song Dynasty, there were some Cuju masters who entered the road with the ball and went straight to Tianting

Sildenafil has passed the FDA's review, which means that some players have entered the Premier League. If they sell well, they will become famous, Hu Chi naturally wants to know the details.

If he wants to know, Yang Rui will introduce him.

He first talked about the review process of clinical phase III and clinical phase IV, then about the later negotiation with Pfizer, and then about the contract and sales policy of greenstone corner, and then about the performance of sildenafil in the market, as well as several modes of withdrawing funds.

Hu Chi didn't understand.

90 The Chinese in 1949 knew very little about foreign countries. Even Hu Chi, a pseudo senior official, did not understand the professional situation in the field of medicine.

After listening for a while, Hu Chi finally gave up and decided to start with what he understood. He said with a smile: "in this way, you still make money. Ha ha ha ha..."

"Earning is earning. Speaking of this, I'd like to talk about where the funds go." Yang Rui also stated the goal of his trip.

Hu Chi nodded again and again: "the capital has to be spent to have value, you say."

"The ion channel Laboratory of Peking University is ready to participate in the genome project. The instruments, equipment, personnel and training have been completed. Would you please come forward and urge the negotiation?" The human genome project is an international cooperation, that is, a national project, so it needs to be discussed on a national basis. Of course, Yang Rui has already finished the communication in the early stage. There are few professional parts left, and the rest are all political and diplomatic work.

But political diplomacy is also the most complex part. In the context of international cooperation and confrontation, no one knows whether they will become a bargaining chip.

90 The international situation in 1980 was very unfriendly to China, which is quite different from that in the mid-1980s.

When Yang Rui won the Nobel Prize, the media praised him everywhere. There was even a voice within the Nobel Prize Committee, hoping to give China a Nobel Prize and promote the development of China's democratic cause from the side

But after 90 years, the voice of the media has completely changed, and everything in China will become wrong.Almost all Yang Rui's cloned sheep are regarded as a threat

This is the political correctness of the western world, and it is also what the various committees care most about.

If the pharmaceutical companies are really strong, the pharmaceutical system is really rich, the lobbying group is really powerful, and the mouth guns really need to use it, the passage of sildenafil will be subject to various restrictions.

Therefore, Yang Rui's attitude towards joining the human genome project is not very casual.

Hu Chi also knew the difficulty of the matter and pondered: "you also know the current diplomatic situation. I can only say that I do my best."

"En..." Yang Rui rubbed his chin and said, "if necessary, Peking University can provide some help, such as funds and personnel."

As far as his current influence is concerned, it is OK to represent Peking University.

As long as a project such as the human genome project is won, the influence of Peking University will be greatly enhanced, which is a good thing that both sides are looking forward to.

Hu Chi didn't expect Yang Rui to say that. He couldn't help laughing: "sildenafil is the only one. They should also help."

"It's better to give something concrete." Yang Rui gave the money generously. Greenstone corner lobbied in the United States and spent tens of millions of dollars, tens of thousands or even hundreds of thousands of dollars to hold seven or eight cocktail parties. It has been three and a half years since greenstone corner returned home in the United States.

A unit like the Ministry of foreign affairs is very happy for the staff of the Ministry. Even if it doesn't need any gray income, it can make a lot of money by saving a little travel expenses and buying some foreign specialties. But for the unit itself, the cost of every business trip is in foreign exchange, which is not rich.

In fact, there are police stations, criminal police teams and other units. Although the employees are moistening on weekdays, when it's time to handle cases, the expenses of driving thousands of miles to collect evidence and staying for a long time are not a small amount.

That's why Yang Rui often donates money to the police departments under his jurisdiction. In the same way, he doesn't care if he donates money to the foreign affairs department.

If you don't count plug-ins, what's the difference between him and his contemporaries? Apart from Yan Gao, the main thing is money.

If we want to analyze it carefully, we should be rich and generous.

Other domestic scholars, even if they get a large amount of money, because of their past experience, most of them will also use it. This is an era when people still regard frugality as a virtue.

Yang Rui didn't have this habit. His scientific research reached its peak. In fact, it was krypton gold.

If you want to improve any advanced skills, you have to spend one time, dozens of times or even hundreds of times.

1990 In China, I was used to doing follow-up research. To put it simply, I was used to following big guys, and I didn't have the consciousness to go global myself. I naturally like to consider cost performance when I spend money.

However, it's never cost-effective to be server first.

Although Hu Chi was not used to such straightforward operation, he accepted Yang Rui's insistence and said, "in this way, you have to consider the problem of domestic competition."

This is his intention to raise Yang Rui.

Yang Rui was not his first brother. He asked with a smile, "have you received any news?"

"You know where I am now, there are always people who will come to test me." Hu Chi first explained, then said: "peach pickers are always indispensable."

"Do you think they can take it?" Yang Rui asked a little seriously.

Throughout the country, Yang Rui is not the only one calling for the human genome project.

Despite Yang Rui's frequent calls for the human genome project and even the Nobel Prize, when the national team decides the order, it is never judged by the sound size and frequency.

They can bring up the scholar who first called for the human genome project, or they can bring up the oldest qualification, or they can even bring up a member of the academic department to take the lead.

The Nobel Prize is only an award, not a qualification. It is the member of the faculty.

Moreover, such as Professor Cai, Wu Hongbo and academician Zhu, their international reputation can not be compared with Yang Rui, but their domestic reputation is not weak at all.

At that time, the human genome project will be established. It is not impossible to give Yang Rui a deputy group leader and then hang up the group leader.

Of course, Hu Chi was supportive of Yang Rui, so he specially reminded him and said, "if you pay attention, there should be no problem, but you can't ignore it."

Speaking of this, Hu Chi said: "you can attend more meetings recently. I'd like to remind you. In addition, you can also bring up the human genome project again and set up a preparatory group."Yang Rui was a little annoyed and said, "how can I have time to do so many useless things..."

The preparation group or something is to line up to eat fruit, to settle other people, everyone is happy, but not to rob.

It's like making a promise to each of you, and then maintaining your own high position.

But Yang Rui is also reluctant to do so.

It's not as easy as he thought, and it's not his specialty. The most important thing is that the human genome project is to really do things. Who will do the work for a group of old people?

Hu Chi asked, "what do you have to do recently?"

Yang Rui broke his finger and said, "I have to have a class. Huarui also has to consider developing new drugs. The ion channel laboratory and Huarui laboratory also have routine research. In addition, I plan to make a medicine valley."

"Medicine Valley?"

"It's like a development zone to concentrate some pharmaceutical related enterprises, but Huarui does it by itself. It doesn't pursue short-term benefits, and there's no trouble for the development zone to take care of this and that. It's just to concentrate industries and concentrate some enterprises. In addition, we only rent but don't sell supporting houses for enterprises, so as to reduce their worries." Yang Rui stopped for a moment and said, "the loan line given by Bank of China is nearly 10 billion. We have to use it."

"Large scale?"

"Now it occupies a large area of Pudong, and Shenzhen also gives a large area of land. It can accommodate hundreds of enterprises, and there is still room for them. " Yang Rui stopped, understated: "the factory is built by the enterprise itself, but in order to attract the pharmaceutical factory, we have to undertake a large number of residential construction. At present, it is estimated that it can accommodate at least 500000 workers, plus the follow-up, that is 1 million suites. The amount given by Bank of China is just right."

Hu Chi's eyelids are jumping: "the loan is not to return it?"

"There are still follow-up profits. Besides, isn't there a rent? If it is handed over by various units, it will also save a lot of trouble. "

"But... A million units?"

"Take your time. Don't worry. Bank of China's loans are not unconditional, and they are willing to invest in infrastructure. If it's all used to make new drugs and buy machinery and equipment, they won't be at ease. "

"So is this one, but you have a big plan."

Yang Rui laughed twice and said, "I just put forward an idea. As a result, the governments of the two places are too active. They sell land cheaply and subsidize it with policies. They can't do anything about it. It's getting bigger and bigger."

"Then you must be careful not to fill the gap in time."

"Bank of China's loans are made in proportion to our US dollars, and the risk is not very great." Yang Rui laughs two times, more or less guilty.

How much will the 1 million Suites in Shanghai and Shenzhen be worth in 20 or even 30 years? Yang Rui himself is a little afraid to calculate. He can only say that if Huarui wants to develop new drugs in the future, the rent will be enough.

There are a lot of state-owned enterprises that live on rent, but it's not bad for a private enterprise.

For Yang Rui, Yaogu is really to solve the current problems.

Bank of China's loans should be spent, and they should not be spent in places with too much risk. Otherwise, people will have to intervene. In this case, infrastructure investment is the best choice. On the other hand, Huarui also really needs to have a centralized industrial base in big cities. With the hot sale of sildenafil, Huarui's sales network across the country has been greatly enhanced, and its brand has gradually become loud. At this time, we can't just look at the development of high-end new drugs.

With China's industrial scale and consumer market, once we get involved in the production of various generic drugs, the industrial park with hundreds of thousands of workers can't really be ahead of time.

As for the 1 million apartments, in this context, it is more to increase Yang Rui's personal satisfaction - everyone knows that the house is flying, so it's unreasonable not to buy two more.

To this end, Yang Rui also to provide high standards of housing for the reason that the housing will be built as large as possible.

Where did Hu Chi guess Yang Rui's idea? As soon as he changed his mind, he went back to the previous topic and said, "since you want to be a medicine Valley, it's better. In the name of the chemical and pharmaceutical revitalization office, I'll promulgate the GMP standard you made before in advance."

"Now?"

"All policies and regulations are ready. If they are implemented on January 1 next year, we can start reviewing them this year. This matter has always been promoted by you. It happens that you also need to spend time to understand the situation of various pharmaceutical companies, so it's up to you. How about dividing the existing GMP committee into another committee? " Hu Chi took it for granted and showed full respect for Yang Rui.

Yang Rui was surprised, but also saw the murderous.Hu Chi said that the GMP standard is a rigid standard for pharmaceutical enterprises. If it fails to pass, the result will be closure, suspension and transformation.

As a designer of standards, Yang Rui is well aware of the difficulties of standards. In history, there are more than 4000 pharmaceutical companies in China, and in the end, there are more than 2000, including half of the newly-built pharmaceutical companies, which are facing the crisis of annexation or bankruptcy.

The Committee in charge of the standard audit and its responsible person are holding the life and death power of all pharmaceutical enterprises in China.

In this kind of comprehensive audit, even the famous enterprises may be eliminated because of some shortcomings. Yang Rui looks at Hu Chi and doesn't say anything for a moment. Such an important decision can't be suddenly thought of by clapping his head.

Hu Chi, however, pretended to be silly and said: "you are in charge of the GMP audit committee, and you have the right to do it. It's convenient to do any medicine, and no one dares to pick your peaches, right?"