Chapter 359

"Come on, let's go to the Cancer Institute!"

After reading Lu Li's paper, professor he quickly got up, "let's go to the laboratory to verify it."

If it is the paper of irrigation nature, naturally there is no need to verify it. Lu Li's work is of great scientific research value, and it can even be said that it is a great pioneering achievement. Naturally, it has to go through comprehensive and detailed verification.

So Professor He and Lu Li hurried out of the office and all the way to Fudan Cancer Institute.

"Lao Guo, Lao Guo, come on!"

Into the Cancer Institute, Professor He Yang in the hands of the papers, shouting all the way.

"Yes! Here I am

Professor Guo's head came out of the door of the office.

Seeing that Professor He ran over excitedly, followed by Lu Li, Professor Guo quickly asked, "Lao he, why are you shouting so much?"

"Lu Li has got the research results. Organize people to verify them."

Professor he's feet are flying. He shouts as he walks.

Research results?

Hearing what Professor He said, Professor Guo was stunned and looked at Lu Li's eyes with a bit of astonishment.

So that's the result?

It's only two months since we last released the improvement plan of car-t technology, isn't it? Again?

The busy graduate students and doctoral students nearby also stopped one by one and looked at Lu Li one after another, thinking: have you made any achievements again?

"Lao Guo, come and have a look!"

Professor He, with his face full of red light, walked briskly into Professor Guo's office and stuffed the paper materials into Professor Guo's hand. "Quick, organize verification."

"What's the matter? I'll see first

Professor Guo was still calm, ignored the shouting of Professor He, took over the papers and read them.

"The application of gene editing technology of T cells and B cells in car-t technology."

Application?

Seeing this keyword, Professor Guo's eyes beat a few times. Dare to write the application on the title, is it Is Lu Li sure this technology is mature?

Car-t technology is mature. What is the concept?

As a research leader of cancer research center, how can Professor Guo not know car-t technology?

This new technology is still in the exploratory stage. Once it matures, it is We have found the specific drug for cancer treatment and the most reliable technology for cancer treatment.

From a clinical point of view, this has been considered to conquer cancer!

If this technology is true, if it is feasible and reliable after verification, then This scientific research achievement of Luli will be a great historical breakthrough!

We are witnessing history!

Professor Guo set off a huge wave in his heart, and his hands holding the data were shaking slightly.

Taking a deep breath, Professor Guo helped his glasses and looked at the paper seriously.

Every word, carefully, seriously study.

Modify T cells, put cancer cells on the "hostile list", and weaken the ability of T cells to "summon friendly forces". This is the research result before Luli.

Now, in this paper, Lu Li gives a new idea. On the basis of modifying T cell gene, Luli further modified B cell gene, making B cell shield "logistics and command ability".

Theoretically speaking, Lu Li's idea is right and feasible.

It's just To achieve this goal, it involves very specific gene editing and modification technology.

To accurately modify a function of B cells, we need very specific and precise gene editing operations. It is likely that For a long time, we can't do gene manipulation to modify a certain function of B cells.

"The idea is right."

After reading the paper, Professor Guo nodded and looked at professor he and Lu Li again, "but it's too early to talk about application, isn't it? It's just a theoretical research paper of direction, and it can't enter the practical application link yet. "

After putting down his paper, Professor Guo took another look at Lu Li and said, "it will take a long time to accurately edit the genes of B cells, so as to find the correct gene targets and select the gene fragments we want to edit. Let's do this research first. "

"No!"

Professor he laughed and took out another piece of information, "the experiment has been done. This is the report of the experiment

"Eh?"

Professor Guo widened his eyes, "have you done it?"

He snatched the experimental report from Professor He, and Professor Guo read it carefully again.

In this experiment report, Lu Li wrote out every step of the experiment in detail, including reaction time, ambient temperature, humidity, reading of equipment and instruments, etc.

This Did it really work?

Lu Li has completed all the experimental steps, only one result is needed to verify.Professor Guo raised his head and looked at Lu Li. The corners of his mouth were shaking, "you All the techniques for B cell gene modification have been completed? "

"Yes

Lu Li nodded, "we come here this time just to verify the results on your side."

"In more than two months, B cell gene editing technology was developed. How do you find the right gene fragment? How do you position yourself? "

Professor Guo is still a little unbelievable.

I did the first experiment in the virtual laboratory!

For more than two months in reality, I didn't know how many more experiments I had in the virtual laboratory and how much time it took to find the correct gene fragment.

Of course, Lu Li can't say that, he can only say: "maybe it's good luck? It happened that I found the right gene fragment for B cell gene editing

Luck

This reason is so powerful that Professor Guo is speechless.

Scientific research is a process of trial and error. In this infinite trial and error link, luck is the first.

If you're not lucky, you may not be able to find the right gene fragment from the three billion base pairs in a year or two, or even more than a decade.

With luck Maybe just like Lu Li, he found his goal in just over two months.

So even scientists have to talk about luck.

"Go! We'll verify it right away! "

Professor Guo didn't worry about his luck. He quickly got up and walked out of the office. He yelled at the busy postgraduates and doctoral students outside: "stop your work, go to the gene lab immediately, do a scientific research verification, hurry up!"

Is it scientific research achievement verification again?

Is it Lu Li's scientific research achievement verification again?

We can only follow our tutor's experience, but you constantly produce scientific research results.

It's really It hurts my self-esteem!

The research dogs, driven by Professor Guo, run up one by one. When passing by Lu Li, they slightly lower their heads.

When everyone came to the gene lab, Professor Guo asked Lu Li to lead the experiment and direct many research dogs to do the experiment.

A group of postgraduates and doctoral students started to work for Lu Li. They kept extracting B cell samples, preparing transcriptase and shear protein.

Lu Li sat in front of the test bench, and all kinds of experimental materials poured into his hands.

Turn on the electron microscope, turn on the gene gun, and constantly edit the B cells. One by one, we have done more than 100 times.

"Test passed! We have obtained the samples of gene modification

After more than 100 gene modifications by Lu Li, Professor Guo, who carried out the tests later, has found the B cell sample that has completed the gene modification accurately.

"Yes! B cell gene editing technology, the verification is successful! "

Professor he could not help cheering.

"Congratulations

"Lu Li, Congratulations

There was a burst of applause in the laboratory, and everyone congratulated Lu Li on his successful technical verification.

This verification has proved that the B cell gene editing technology is successful.

It's normal to make more than 100 times to accurately prepare the required gene modification samples.

With the current gene editing technology, even if we find the correct gene fragment to be edited, it is impossible for the splicing protein and transcriptase to accurately cut the required position at one time, and it often cuts the wrong place.

After 100 experiments, one specimen with correct gene editing can be obtained, which is the reason why Lu Li has determined the experimental data. This result is already very good.

If you don't have this experimental data, you don't know how many years of experiments you have to do to hit the right spot by chance!

"B cell gene editing technology, has passed the verification!"

Professor Guo also announced the results with excited face, and then said: "the next thing to do is to verify the car-t anti-cancer technology."

"This verification will take some time."

Professor he took over the conversation, turned to Lu Li and said with a smile: "however, your theoretical research paper can be published. The experimental data should be kept secret! "

"I understand!"

Lu Li nodded, "the achievement verification of anti-cancer technology needs to be arranged by Professor Guo."

"No problem."

Professor Guo agreed without hesitation.

……

In the afternoon of that day, China Medical Journal received another paper from Fudan University.

"The application of gene editing technology of T cells and B cells in car-t technology."

Seeing this title, the editors of "Chinese medicine" are worried about the application? Is car-t technology mature?

See the author of the paper again Luli!

Another Luli!

How many months? Has Luli studied car-t technology to the extent that it can be applied?The editor is also half an expert. Naturally, he knows the significance of the maturity of car-t technology. This is tantamount to announcing to the world that cancer is no longer an incurable disease, and cancer can be treated!

This Luli It's amazing!

With a deep admiration, the editor of the magazine quickly forwarded Lu Li's paper to the reviewer without hesitation.

……

"At present, car-t technology is not mature."

In an auditorium of Yanjing University, oncology expert, Professor Wang Zhijian of Union Medical College, is giving an open class.

"Fu Dan's youth learned from Lu Li and made a great breakthrough in this technology. However, the problem of immune factor storm has not been solved

"Science and technology are changing with each passing day. I believe that with the passage of time, maybe five years, maybe ten years, we will be able to overcome cancer, a stubborn disease accompanied by human genes. "

"Of course, this requires the students here to study hard and study hard!"

Just then, Professor Wang Zhijian suddenly saw that his assistant waved to him with his mobile phone. He seemed to be a little excited and a little anxious.

Huh? What's going on?

Professor Wang Zhijian frowned. The assistant is his student. Normally, an assistant can't disturb him in class.

Since the assistant is doing this, there must be something very important.

"What's the matter?"

Professor Wang Zhijian stopped, turned his head and looked at his assistant, his face a little unhappy.

"Professor, Chinese medical journal, I have a manuscript that you need to review."

Assistant Yang Yang mobile phone, hurriedly answer.

"Peer review? That's it? "

Professor Wang Zhijian's face is not good-looking, "on this matter, you dare to interfere with my class?"

"Professor, this article It's important! "

Assistant quickly said: "this is Lu Li's paper. The latest papers on car-t technology. "

Huh?

Professor Wang Zhijian was shocked, Lu Li? The latest car-t technology?

"Bring it here!"

At the risk of interfering with the class, it is absolutely important to send the manuscript to see. Professor Wang Zhijian quickly asked his assistant to take the mobile phone.

Because the audio equipment was not turned off, the students sitting in the auditorium also heard the conversation.

So There was a lot of discussion in the classroom.

"Lu Li? Is that Lu Li of Fu Dan? "

"Has Luli developed new technology?"

"Since you dare to disturb Professor Wang's class, it must be a very important paper."

"Has Luli made another breakthrough in car-t technology? Has he matured this technology? "

"It should not be possible. Didn't you listen to Professor Wang? Five or even ten years later, it will be possible to develop a mature car-t technology. "

When the students are talking about it, Professor Wang Zhijian is a little stunned.

"The application of gene editing technology of T cells and B cells in car-t technology."

This paper is a theoretical direction of the paper, the text of T cells and B cells of gene editing technology, made a directional expression.

In fact, this kind of paper can only be used as a reference, and has not much practical value.

However, the title of this paper dare to write the word "application", and at the end of the paper, there is the repeated experimental conclusion of Fudan University.

That means This technology has been proven. At least in the B cell gene modification technology, Lu Li's paper is completely correct.

The younger generation is formidable!

Professor Wang Zhijian restrained his shock, put down his mobile phone and went to the platform.

"Students, I just received a paper."

Professor Wang Zhijian said to the students, "this is a paper on car-t technology published by Lu Li of Fudan University."

"In this paper, Lu Li proposed a new research direction and completed the preliminary verification."

Speaking of this, Professor Wang Zhijian stopped for a moment and said, "just now, I said that car-t technology will take five years or even ten years to mature. Maybe I'm wrong

"Although the new generation car-t technology developed by Luli still needs clinical trials to prove its efficacy. But, in theory, maybe He's got cancer! From now on, cancer is no longer an incurable disease! "

"Lying trough!"

"My God

At this moment, there was an uproar.

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