Chapter 358

After preparing this B cell, Luli immediately carried out human experiments.

This is another great advantage of virtual laboratory.

If it is a normal experimental procedure, it is necessary to carry out experiments on various small animals first. After a long time, it is possible to carry out human experiments.

Even In many scientific research projects, there is no chance for human experiments.

Luli is different.

In the virtual laboratory, everything is virtual, and it's all fake. He can do experiments on human body at will. He can do it if he wants, without any restrictions at all.

It's the same this time.

Lu Li directly injected the modified B cells into the experimental human body.

And then Nothing happened.

Huh? Why?

In a daze, Lu Li quickly picked up the detection equipment and carefully examined the experimental human body.

Then, Lu Li found the reason!

B cells, which block the ability to receive information, are also a "quiet beautiful man"!

If it doesn't receive any information, it will return to the lymph node with the lymph fluid and stay in it motionless and leisurely.

On the contrary, other B cells in the human body, after receiving the information, copy crazily and release immune factors crazily, causing the immune system to go crazy.

So B cell "shut down" also can't!

What should we do?

Lu Li has a headache!

Come on, take a break. This more than a month, every day at home to do research, people are rusty!

After closing the virtual laboratory, Lu Li got up and went out to run around the artificial lake of Binjiang garden!

While running, Lu Li suddenly saw a girl in front of him doing morning exercises.

This girl is wearing a white tight sportswear, and her figure is It's really forward and backward. It's really rough to run.

Fortunately, Lu Li's will is as strong as steel. Even when he sees such a provocative scene, he has no fluctuation in his heart.

Even thinking The weight of the chest and buttocks is too large, which affects the coordination of human movement. This kind of body structure, does not conform to the natural law, in the cruel natural competition, will be eliminated by natural selection!

The next moment, Lu Li thought of Human beings no longer need to bear the cruel natural selection! This body structure, on the contrary, is more suitable for gene transmission.

So, what's going on in the brains of research dogs?

While Lu Li was thinking about serious scientific problems, her sultry sister heard the footsteps behind her and turned to look over.

Seeing Lu Li's handsome face, tall and straight figure and strong muscles, the girl flashed a light in her eyes and a smile on her face.

"Hi

The younger sister waved to Lu Li and took the initiative to say hello.

Er Because of my handsome face, because of my strong body, it is very suitable to be a combination of gene transmission, so, under the control of gene instinct, she took the initiative to say hello to me.

Sure enough, humans are just tools dominated by genes!

Love is just the instinct of gene transmission, family affection is just the instinct of protecting gene continuity, and human beings are just tools dominated by genes.

A series of scientific explanations came out of his mind, and Lu Li responded with a "Hi!" with a smile

Nothing else, mainly It's too big!

It's still a genetic instinct!

"Do you live here, too? Why haven't I seen you before? "

Sister slowed down and ran side by side with Lu Li.

"More than a year."

Lu Li replied and asked, "do you live here, too? I haven't seen you before

"Just a few days ago!"

My sister laughed, "I used to be in Beijing. My sister lives here. I'm here to see my sister! "

"Oh! The capital is a good place

Lu Li nodded, "I've been in Beijing for some time before."

That's in the plot. Lu Li spent a long time in Beijing.

"Is it?"

While she was running, her white face was slightly sweating, and there was a strange beauty of jade ball.

"My name is Wenwan, and you?"

The younger sister introduced herself and then turned to ask Lu Li.

"My name is Lu Li."

"Lu Li?"

Without waiting for Luli to finish, Wenwan exclaimed, "are you Luli who developed the new car-t technology? oh my god! I didn't expect to meet you here. What a coincidence! "

"I'm not that well known, am I?"

In today's society, people only pay attention to the star's fringe news. Who cares about the research dog?

"Introduce yourself. Wen Wan is a graduate student of basic medicine in Peking Union Medical College

Wen Wan smiles at Lu Li, "don't you know how famous you are? You are our idol"Oh! So it's a colleague! "

Lu Li nodded, "no wonder you know me."

"Big brother, add a wechat!"

Wenwan takes out her mobile phone from her Sports Wristband bag and raises it to Lu Li.

"Wechat?"

Lu Li's step made a flash in his mind.

Yes! WeChat!

I thought wrong before!

Why shut down B cells? Why can't B cells receive information? As long as I can't send "wechat" and "circle of friends" to B cells, it's OK!

B cells receive the information from dendritic cells, immediately activate the stress mechanism, and constantly divide and proliferate.

And then After the modification of these genes, B cells that "can't send wechat" and "can't send circle of friends" occupy the positions of other normal B cells in a large area, and then "die a vegetarian meal" and do nothing!

In this way, the probability of immune factor outbreak will be greatly reduced!

"Ha ha ha ha!"

Lu Li burst out laughing, turned around and ran away.

Behind her, gentle girl's face is dull!

What do you mean? I asked you for a wechat. Is it so funny?

What do you mean by that?

Are research dogs so straight? You deserve to die!

The gentle girl stamped her feet heavily, and her face was depressed!

……

Lu Li suddenly enlightened, found a breakthrough, where will pay attention to what sister?

As soon as he ran home, regardless of his sweating, Lu Li directly lay on the sofa, closed his eyes and opened the virtual laboratory.

"A virtual experimental human body with advanced cancer!"

Came to the virtual laboratory, Lu Li directly ordered, and quickly put on a white coat, walked into the operating room.

After taking samples from the experimental human body, Lu Li picked up several samples containing cancer cells, T cells and B cells, and then hurriedly sat down in front of the test bench to continue the experiment.

The car-t experiment was performed to prepare the required T cells, and then the B cell samples were taken out to start the gene modification of B cells.

The direction is right. The experiment is going well.

Lu Li modified the B cell gene with the splicing protein, which blocked the ability of B cell to transmit information.

And then Lu Li picked up the B cells and injected them into the experimental human body. Then car-t technology was used to inject the genetically modified T cells.

The next moment Miracle is born!

The "hostile sequence" of T cells discovered the cancer cells in the experimental human body, immediately stimulated the immune mechanism, frantically divided and proliferated, and launched a fierce attack on the cancer cells.

At this time, the T-cell army sent out to let the "intelligence officer" dendritic cells detect, and quickly sent messages to the B-cell, constantly calling for reinforcements, and constantly reporting the "outbreak of war" news.

Normal B cells are activated and proliferate immediately. However B cells, which have been genetically modified, are also proliferating violently.

In this way, a lot of B cells of "a simple diet" occupy the posts of logistics and command. Their inaction slows down the immune mechanism.

The "immune factor storm" did not break out in a large area, nor did it cause the immune system to go crazy in a large area.

Although the experimental human body is still feverish and the immune response is still very intense, there is no phenomenon that the immune system attacks important organs indiscriminately and does not lead to heart failure, lung failure, and other visceral failure.

The experiment is successful!

Lu Li laughed.

Lu Li was very happy with the pleasure of conquering a scientific research problem and the achievement of technological breakthrough!

From a certain point of view, car-t technology has clinical value!

It reduces the immune response, avoids the storm of immune factors, avoids the immune system's indiscriminate attack on the human body, but can accurately kill cancer cells, which is the best way to treat cancer.

It's just This is still not a radical cure.

Once T cells kill cancer cells in the body, they will self destruct and will not exist in the body for a long time.

And then After a period of time, maybe three years, maybe five years, or ten years, the cancer cells will reappear.

People who have cancer are branded with genes of cancer cells in their DNA. Recurrence is inevitable!

Of course, after recurrence, car-t technology can still be used for treatment!

However, there will be a new problem. Cancer cells are likely to have new mutations in the fight against T cells, and they are likely to have the ability to resist T cell attack.

Just as the virus will continue to mutate, the evolution of cancer cells is almost inevitable.

So Although Lu Li has worked out the best treatment for cancer, he has not fundamentally conquered cancer!Lu Li is still not very satisfied with his research results.

……

After closing the virtual laboratory, Lu Li took a bath, changed his clothes, sat down at the computer desk and began to write his thesis.

"The application of gene editing technology of T cells and B cells in car-t technology."

Lu Li put forward a new theory. Based on the modification of T cell's "identification friend or foe system" and "call friendly forces", he further proposed a scheme to shield B cell's command ability.

This is a mature technology, which can be used in clinic.

The paper is open to the world. In this paper, Lu Li only expressed the theory, but did not express the experimental data and specific operation methods.

Immature technology can be made public. Mature technology, it must be kept secret.

After writing this paper of pure theoretical description, Lu Li wrote a detailed experimental report, which indicated the experimental data and experimental steps.

Lu Li is going to give this experimental report to Fudan medical college. As for how he plans to deal with this scientific research achievement, that's what the leaders consider!

After writing the paper and the experimental report, Lu Li took the U-disk exam and rushed to Fudan medical college.

"Xiaolu, are you here?"

Seeing Lu Li coming, professor he said with a smile, "are you Have you submitted your graduation thesis? "

"Well!"

Lu Li nodded, "teacher, I wrote a paper on car-t technology. Have a look. "

With that, Lu Li took out the U disk and copied the paper and experimental report into Professor He's computer.

"I'll have a good look at your graduation thesis."

Professor he reached out to pick up the mouse and opened Lu Li's paper.

"The application of gene editing technology of T cells and B cells in car-t technology?"

Seeing this title, professor he was shocked. He turned his head to look at Lu Li and asked repeatedly: "application? You mean application? Are you sure? "

It's not an easy word to use. Dare to say "application", that is already mature technology!

Is car-t technology mature enough to be applied?

Is Lu Li telling me that he has conquered cancer?

Professor he took a deep breath and felt that his heart was about to burst out.

"I think the technology is mature. Take a look first! "

Lu Li has done human experiments. Although it is a virtual human experiment, it is no different from the real human experiment.

This technology has been verified!

"Good! I'll see first

Professor he took a sip of his tea cup and tried to restrain his shock and excitement, but The hands holding the teacup are trembling!

Calm down, Professor He opened the paper and read it from beginning to end.

This time, professor he almost knocked over the teacup!

T cells were modified to calibrate the gene characteristics of cancer cells. This step is the open technology of car-t. people all over the world who study this project know this step.

Then there is the second step. Luli makes further modifications on T cells to block the information transmission mechanism of T cells, so that T cells will no longer "call for friendly forces".

This step of operation has been made public in Lu Li's last paper, and has been verified by major scientific research institutions all over the world. It is even the best way for countless cancer hospitals to treat patients with advanced cancer.

Now, in this paper, Lu Li has given the third step, which is to edit and modify B cells' genes to shield the command ability of B cells, so that they will no longer release immune factors crazily.

Theoretically, this is a feasible scheme.

Close the paper, Professor He opened the next experimental report.

In the experiment report, Lu Li described all the operation steps in detail and wrote all the experimental data.

This experimental report is very detailed and can be used for repeated experiments.

Of course, Lu Li did not write out the data of human experiment. After all, it is not so easy to do human experiment in reality.

After reading the paper and the experimental report, Professor He raised his eyes and looked at Lu Li, but his face was still dull.

"So Have you conquered cancer? "

Dull for a while, professor he burst out laughing: "ha ha ha! My students have conquered cancer! "

"This is a great scientific research achievement! From today on, cancer is no longer a human nightmare

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