Chapter 357

As for the so-called "major breakthrough", Lu Li does not think much of it.

Even if the information transmission mechanism of T cells is blocked and the ability of T cells to call friendly forces is limited, the immune response is still very intense.

The treatment with stronger side effects than the treatment is undoubtedly unsuccessful.

But So far, the side effects of all anti-cancer methods are more severe than the therapeutic effect.

The commonly used radiotherapy, while killing cancer cells, kills more normal cells, and radiation is carcinogenic, almost like drinking poison to quench thirst.

Chemotherapy is more cruel! It's totally killing the enemy by one thousand and losing three thousand.

As for the most advanced car-t technology, the lethal effect is far greater than the therapeutic effect.

However Even if the side effects are so huge, there are still countless people who want to be treated.

Suffering from a terminal disease and watching life pass by day by day, people do not care about the side effects at all. Even if there is only one in ten thousand or even one in ten thousand hopes, they should try.

Therefore, Lu Li actually underestimated his scientific research achievements.

……

Milligan.

In the ward of a private hospital, an old man was lying on his bed, next to a doctor in a white coat.

"Dr. Henry, are you here today to tell me that there is no hope?"

Old face, a pair of turbid eyes, showing a deep unwilling.

"No! On the contrary, sir

There was a smile on Dr. Henry's face. "I bring you hope!"

"Hope?"

The old man's eyes were full of light. "This is the best news I've heard recently! So Where is my hope? "

"Car-t technology!"

Dr. Henry replied: "Sir, a few days ago, a Chinese scientist named Lu Li improved car-t technology, which can greatly reduce the factor storm caused by immune response. So Your hope has appeared! "

"Thank God!"

The old man stretched out his hand and crossed his chest.

"You should thank the Chinese scientist Lu Li!"

Dr. Henry thought: God didn't save you, but Lu Li's research achievements may save you!

"Yes! Thank you, Lu Li

The old man's eyes were full of hope.

……

The same scene is happening in many parts of the world.

Luli's improved car-t technology and gene editing technology, which block the information transmission mechanism of T cells, have brought a glimmer of hope to countless desperate people.

This new technology, which is still very immature and can't even be said to be successful, can't save all people's lives.

Only those with weak immune response or strong physical fitness who can carry the immune response will gain vitality.

However For people in despair, this hope is their motivation to stick to it.

In the next month, there will be hundreds of cancer patients who have survived because of the new technology.

For a while, Lu Li and his T cell gene editing technology have been widely concerned by the medical community, and also have a huge impact on the society.

"China's young scientist Lu Li has opened a new chapter in the fight against cancer!"

"Lu Li invented a new technology to treat cancer. No radiotherapy, no chemotherapy, no surgery. "

"Genes are the future. Talk about the impact of genetic engineering on human beings from the perspective of T cell gene editing technology of Luli. "

"How far are we from conquering cancer? Lu Li tells you, this day is just around the corner! "

There are news reports about Lu Li in newspapers and on TV.

On the campus network of Fudan University, the floating good news came out: "congratulations to Lu Li of our university for his breakthrough in car-t technology!"

The upsurge of new anti-cancer technology also spread to Xichuan and Yucheng.

When Xichuan TV station and Yucheng TV station learned that Lu Li was one of their own, the publicity became more lively.

"Our news: Lu Li, a young scientist in China, has made significant scientific research achievements in car-t anti-cancer technology and created a new technology for the treatment of cancer."

"Lu Li, from Yucheng, Xichuan..."

Mother Lu, who sells vegetables in the vegetable market, looks up in surprise and looks at the TV screen hanging on the wall.

Lu Li? My son?

My son is a scientist?

Mother Lu rubbed her eyes and looked at it for a while. She found that the picture on TV was Lu Li, her son.

Some time ago, my son sent some money to his family, saying that he was going to Fudan to study as a graduate student.

Now Turned into a scientist?Standing for a while, Lu's mother "again" burst out laughing, "again" began to show around: "my son! This is my son! My son is a scientist

"Sister Lu, is your son a scientist? How wonderful

"Yes! Yes! Scientists! How wonderful

Everyone around him was full of envy and admiration.

Later, mother Lu's food was free again. Father Lu called his friends to treat him with wine again.

Er Why do you say "again"?

……

"Congratulations, Lu!"

Professor he put down his newspaper. The front page of the newspaper was a picture of Lu Li.

"Thank you

Lu Li laughed and said, "car-t technology is still immature. The praise from the outside world is a bit exaggerated."

"Don't belittle yourself!"

Professor he said with a smile: "your improved car-t technology is one of the most effective means to fight cancer at present."

At this point, Professor He took a look at Lu Li and continued: "you have made great achievements in scientific research. I had a talk with President Jiang. We all feel that your knowledge level and scientific research ability have gone beyond the level of graduate students. So you can graduate. "

"Ah?"

Graduate just one year, you can graduate ahead of time?

"In fact, there is no strict time requirement for postgraduate and doctoral students. As long as your knowledge level and scientific research ability reach the standard, you can graduate. "

Professor he explained with a smile, and then asked Lu Li, "after you get your master's degree, which direction do you plan to study for a doctor?"

"Of course, I will continue to learn from you!"

Lu Li felt that his cooperation with Professor He was very pleasant, and he was too lazy to find another tutor. It would be more convenient for him to continue to study under Professor He.

"This..."

Professor he hesitated for a moment and said, "of course, I'm very happy that you continue to study with me. But I'm afraid I can't give you much help in this area. "

"Don't say that. I have a lot to learn from you."

Lu Li has copied the knowledge of countless professors, and his knowledge accumulation has been very rich.

For Lu Li, what he needs is not the guidance of knowledge, but the convenience of scientific research.

Therefore, Professor He, who gets along well, is the most suitable tutor.

"Well All right

Seeing Lu Li's high willingness to continue to study with him, professor he didn't object. "You prepare for it. At the end of the term, you will take the exam together with the graduates of this class, and then prepare a graduation thesis."

"All right!"

Lu Li nodded and agreed.

After leaving Professor He's office, Lu Li returned to Binjiang garden.

Sitting down in the study and turning on the computer, Lu Li was about to prepare his graduation thesis when he saw hundreds of e-mails on his e-mail.

"Why so much mail?"

Lu Li quickly opened his email.

Some of these e-mails are from scholars from domestic research institutions and doctors from cancer hospitals.

There are also some e-mails, which are actually cooperation invitation letters from various companies, and even invitation letters from biopharmaceutical companies.

The salary is very high. Unfortunately, Lu Lizhi is not here, and he doesn't need to hold the thigh of "father of gold", so he is too lazy to pay attention to it.

To Lu Li's surprise, there are also invitation letters from some research institutions around the world inviting him to exchange views.

Among these invitation letters, there is an exchange invitation from the American Society of oncology.

"An invitation from the American Society of oncology?"

Lu Li's face lit up with a smile, "is this sent to me to copy knowledge?"

In terms of cancer research, the American Society of oncology has a solid foundation. These accumulations are also very valuable for Luli's research on the technology of conquering cancer, and are worth copying.

It's just Lu Li has no idea of going to the United States for the time being. Let's get a master's degree first!

He replied to some important mails in his mailbox, but left the others unattended, so Luli closed his email.

Get up, go out of the study, lie down on the sofa, Lu Li closed his eyes, once again opened the virtual laboratory.

Graduation season is two months away.

Lu Li is not worried about the graduation exam at all. It's just I'm going to spend a lot of time on my graduation thesis.

If you just deal with it, the graduation thesis is not difficult. However, before Lu Li was known as a young scientist, he could not fool a graduation thesis.

Let's continue to study car-t technology!

Last time, Luli reduced the intensity of the immune response and the risk of madness of the human immune system by modifying the genes of T cells.This genetic modification is very safe. Because after completing the task of killing the enemy, T cells will rapidly self destruct and will not exist for a long time.

Now, what Luli wants to modify is another kind of immune cell - dendritic cells.

Dendritic cells are intelligence agents in the immune system. They can quickly transmit the information of human being attacked by virus to the immune system, and trigger a violent immune response.

Under normal circumstances, dendritic cells, as intelligence agents, are extremely beneficial to the human body. They are the key to the human body's fight against virus invasion.

However In car-t technology, in order to prevent the immune system from going crazy, weaken or even shield the intelligence ability of dendritic cells, it is more valuable for treatment.

However, dendritic cells exist for a long time and will not self destruct. Once the intelligence ability of dendritic cells is modified, the immunity of human body will be reduced.

This made Lu Li a little tangled.

Once we modify the genes of dendritic cells and weaken their intelligence ability, we may reduce the probability of madness of the immune system and let T cells kill cancer cells smoothly.

However If the cancer stabilizes and doesn't get worse, but the patient dies because of a cold, what's the reason for that?

Experiment first!

Human experiments that can't be done in reality can be done at will in the virtual laboratory without any risk, which is very convenient.

Next, Luli began to edit the gene of dendritic cells.

It is also used to cut the DNA chain of dendritic cells to shield the "intelligence ability" of dendritic cells!

Experiment is trial and error!

The advantage of virtual laboratory is very obvious.

There is no need to spend money at all. No matter how expensive the experiment is, it can be done openly.

One day, two days, one week, two weeks.

Lu Li has done countless experiments, and finally demarcated the "gene fragment" of dendritic cells representing intelligence ability.

After finding the target, it is easy to operate.

The transcriptase labeled gene fragment was injected into the dendritic cells together with the splicing protein, and a dendritic cell with intelligence shielding ability was successfully prepared.

And then Lu Li began to do human experiments.

The dendritic cell, which is shielded from intelligence, is injected into the experimental human body, and Luli begins to observe the reaction of the experimental human body.

And then There was no response.

After testing, Lu Li found that the dendritic cells injected into the experimental human body did not divide or proliferate, and he was a "quiet and beautiful man".

A dendritic cell without intelligence has no effect on the human body at all.

Do you need to modify all the dendritic cells in the human body?

The human body has 60 trillion cells, and dendritic cells, if not many, are calculated in billions. This workload When the patient died, the dendritic cell modification task was not completed.

This road is totally impassable!

Lu Li sighed for a long time, and it was not so easy.

No! I think wrong!

If you don't want to answer the phone, why do you want to collapse China Mobile Unicom? Why don't you just turn it off?

Therefore, Lu Li put the target on another kind of immune cells.

B cell!

If T cells are front-line forces, B cells are logistics and command.

Since we can't block the intelligence ability of dendritic cells, let B cells shut down and can't get the "phone" of dendritic cells.

B cells, as logistics and command headquarters, will not receive information from dendritic cells, so they will not produce immune response and release immune factors, which will greatly reduce the immune system of human body.

What's more, B cells, like T cells, will self destruct after the end of the battle, leaving only a small number in the lymph nodes. Most B cells will not exist in the human body for a long time.

So Modifying B cells is the right direction.

Thinking of this, Lu Li immediately began to move.

It took another month for Luli to identify the gene fragment of B cell receiving information.

That's where the hardest part of genetic modification is. We don't know much about genes. Three billion base pairs. It takes a long time to read them all.

The gene fragment of B cell receiving message was found, and the gene of B cell was modified by splicing protein to block the ability of receiving message.

Finally, a gene modified B cell was prepared!

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