Chapter 362

A list of books sent the gentle girl away.

Seeing Wenwan's trembling shoulder, Lu Li nodded with a smile. Although the foundation is poor, the learning attitude is still very correct! After I got this book list, she was so excited!

It's like How excited are the pupils when they receive a box of exercises?

Greedy for my body? You're thinking about peaches!

How can I have the time to fall in love with you? It's better to go back and do an experiment

Well, professor he kicked me out of the lab.

Then give the chicken a holiday Bah, give yourself a holiday!

Lu Li turned around and walked out of the Research Institute, ready to go out for a walk.

Just walked to Fudan school gate, Lu Li suddenly saw a familiar figure.

Willow catkins fly in March.

The light wind blows the weeping willows on the roadside, like a rippling silk tapestry.

A woman in a light spring dress, walking in the shade of the forest, lotus step light comfortable, come.

"Liu Qin?"

Lu Li is shocked all over. In this plot, can he meet Liu Qin? It's really What a surprise.

"Lu Li?"

Hearing the call, Liu Qin quickly raised his head and saw Lu Li standing at the intersection in front of him.

Straight figure, handsome face, as well as the face of the undisguised surprise, let Liu Qin heart inexplicably tremble.

He stretched out his hand and stroked the hair beside his ears. After calming down, Liu Qin walked up with a smile.

"Lu University scientist, old classmates come to visit, are you welcome?"

Walking to Lu Li, Liu Qinyang raised his hand and said hello with a smile.

"Dream of it!"

In the face of Liu Qin, Lu Li was not iron and steel at all, but very active.

Hearing this, Liu Qin blushed slightly, pretended not to recognize the meaning, and quickly changed the topic, "I didn't know until I read the news, so I haven't seen you for a few years. You are a famous scientist in the world

"It's just a small achievement."

Lu Li said modestly, "what about you? Did you graduate from Harvard? "

Does he know that I went to Harvard for my PhD?

That is to say He's been following me?

Liu Qin's heart gave birth to a trace of inexplicable sweetness. Chao Luli said, "I've got my doctor's degree, and I'm planning to find a job!"

"Looking for a job? With your ability, a lot of units are scrambling for it

Lu Li flattered slightly and said, "if there are too many units and I don't know how to choose Why don't you come to Fudan and become a professor? "

"To be a professor in Fudan?"

Liu Qin looked at Lu Li and said, "does Fu Dan have any advantages?"

"The advantage is..."

Lu Li pointed to himself, "you can be closer to me, a handsome big scientist."

"Cut! Beautiful

Liu Qin turned his eyes at Lu Li.

They chatted and laughed all the way, strolling in Fudan campus.

And then The gentle girl, who had been given a list of books by Lu Li, just saw this scene.

Damn it! What's the situation?

Seeing Lu Li and Liu Qin talking and laughing all the way, Wen Wan's sister was so angry that she was shaking her lips.

In front of me so steel, in front of her you so humorous?

You'll send me a book list with me, and you'll amuse her with her?

I I can't compare with her in any way

Well, it's not like that.

Although I don't want to admit it in my heart, but In contrast, her appearance is not as perfect as Liu Qin's, and her proud Wei'an mind seems to be smaller than Liu Qin's.

But I won't give up! Who's afraid of the man?

Wen Wan took a deep breath, and with a smile on his face, he went up to meet Lu Li and Liu Qin.

"Lu Li."

He said hello to Lu Li with a gentle smile, and then naturally came to Lu Li, who was very close.

"This is..."

Wen Wan took a look at Liu Qin, pretended to be a hostess, and said with a smile, "is this a guest?"

Liu Qin's eyes slightly shrunk, and his heart gushed with an indescribable complexity. This kind of hostess tone Is she Lu Li's girlfriend?

Lu Li also heard the gentle tone of the hostess.

Is that on purpose? You're here on purpose, aren't you? In that case, don't blame me.

So Lu Li looked up at Wen Wan, and his face was full of doubts, "that Who are you? Do we know each other? "

Hearing this, Liu Qin's eyes flashed a touch of splendor.

But Wen Wan grinned with anger.

I met half an hour ago. You sent me a list of books. Do you pretend you don't know me?Asshole!

How dare you do that to me? See how I deal with you!

So, she pinched her thigh, the pain made her tears flow down.

And then Looking at Lu Li with a sad face, she said nothing and looked like a broken heart.

I'll go! Opera master!

Fortunately, I'm not a vegetarian either!

Lu Li looked up at Wen Wan and said with a smile, "this girl, you just pinched your thigh too much. The flaw is too obvious."

"In the future, if you want to pretend to cry, you can use ginger juice, even essential balm. Wipe your fingertips a little, wipe your eyes, and the tears will come out, which will be more hidden. "

"Puff!"

Liu Qin beside can't help laughing.

"Asshole! Can you find all this? Do you have a microscope in your eye? "

Wen Wan bared his teeth, stamped his feet, turned and left. Pretending to cry has been seen through and can't play any more.

"Keen observation is a necessary quality for scientific researchers."

Lu Li waved to Wen Wan, "Wen Wan, please remember to read carefully when you go back. I gave you a list of books, we must carefully read. Next time, I'll check my homework! "

"Damn book list!"

A gentle roar, the pace of escape more staggering!

When Wen Wan ran away, Liu Qin asked Lu Li, "is she your student?"

"No!"

Lu Li laughed and replied, "a graduate student from Peking Union Medical College came here this morning to consult me. I don't think her foundation is very solid, so I gave her a list of books. "

What can I do for you? Asking for advice is just an excuse!

You even gave her a book list? How strong are you?

But When you were talking to me just now, why didn't you have so much steel? It seems that EQ is very high!

Is it because I

Liu Qin blushed slightly, but he was very happy.

In the next few days, Lu Li asked Professor He for a leave and took Liu Qin to play in Shanghai.

Disney, golf, museums, everywhere left two people's laughter.

Life simulator is really wonderful, with a girlfriend, but can talk about countless love!

A few days later, Liu Qin is going back.

"Lu Li, I'm going back. After playing for a few days, my family urged me to go back. "

"Well I'll give it to you! "

Later, Lu left the car and took Liu Qin to the airport.

Before boarding the plane, Lu Li handed a bag of fruit to Liu Qin and said the famous saying: pear is Li, Lu Li's Li.

……

"Xiaolu, did you send your girlfriend away?"

When Lu Li returned to the laboratory, professor he was full of "aunt smile".

"Well, it's back!"

Lu Li nodded, "she is thinking about applying for economics professor in Fudan. We need to discuss it with our family. "

"Oh? Apply for an economics professor? "

Professor he was a bit surprised. Is Lu Li's girlfriend also a bully?

"She is a doctor of economics at Harvard. It should be no problem to apply for an economics professor."

Lu Li replied casually, and did not say much, "Professor, I went to do the experiment."

Harvard doctor of economics? Dr. returnees?

When Lu Li had just made remarkable achievements, there appeared a returnee doctor with the background of studying abroad?

Out of prudence and protection of Lu Li, professor he quickly reflected this situation and conducted a political review of Liu Qin.

……

Lu Li was very happy to meet Liu Qin again.

I fell in love with my real girlfriend again. This kind of feeling It's really amazing.

It's just It's still just a dream.

In this plot, falling in love is only incidental. Lu Li's goal is still very clear. We must find a way to cure cancer.

In the next time, Lu Li spent more energy and time in the laboratory besides sending messages by phone with Liu Qin.

During the day, we do the gene comparison test in the Research Institute, and at night, we continue the gene comparison test through the virtual laboratory.

It's just The progress of this experiment is really frustrating.

There are three billion base pairs in the DNA chain. It's too much work to compare them one by one and confirm the genetic information.

Even if 10000 base pairs of genetic information can be determined every day, it will take 300000 days.

There are 365 days in a year, and only 36500 days in a hundred years. 300000 days

Lu Li just slightly compared the data, and he felt powerless.

What's more, in his daily experiments, Luli could not complete the confirmation of gene information of 10000 base pairs.It can't go on like this!

Is there any other faster way?

Yes!

At present, countries all over the world are studying a new "gene expression" detection tool, which is called "gene chip".

The principle of gene chip sequencing is hybridization sequencing, that is, hybridization with a group of nucleic acid probes with known sequence to determine the nucleic acid sequence. The probe of target nucleotide with known sequence is fixed on the surface of a substrate.

When the fluorescent labeled nucleic acid sequence tatgcaatctag in solution is complementary to the corresponding nucleic acid probe on the gene chip, a set of probe sequences with complete complementary sequences can be obtained by determining the probe position with the strongest fluorescence intensity. According to this, the target nucleic acid sequence can be recombined. (Baidu does not ask me, I do not understand)

a gene chip, microgels integrated with numerous gene probes, in the "gene expression detection", the speed can be increased many times.

However, the current gene chip technology is only theoretical research, and the gene chip with real practical value has not yet come out.

But Theory is enough!

"Virtual gene chip!"

At the command, a light flashed, and a huge glass plate appeared in the laboratory. On this glass plate, countless gene probe arrays are densely integrated.

This is a gene chip.

As long as there is a theoretical basis, the virtual laboratory can produce virtual products.

On the basis of gene chip, with optical cable, console, computer, electron microscope, display and other equipment, a virtual test bench can be formed.

A moment later, all kinds of components were automatically combined to build a huge gene testing platform.

Then, Luli is ready for gene expression testing.

There are 100000 genes that have been identified for gene expression information, but At a base of three billion, 100000 is totally negligible.

Virtual laboratory has another advantage, that is, as long as you think about it, what kind of experimental materials can be made.

So Luli created three billion cells that were missing a base pair.

Install these cells in the solution tank, start the gene detection test bench, let these missing base pairs of cells flow into the gene chip, keep circulating, keep comparing.

On the display screen, all kinds of data are like a waterfall, and gene expression detection is ongoing.

The solution in the solution tank continuously flows through the gene chip, and is recycled continuously and circularly.

It's much easier!

Just wait for the test to complete and get the final result.

Lu Li let out a long breath, abandoned the huge amount of repetitive work of gene detection, and began to study more interesting gene targeting technology.

At present, in gene editing technology, it is still a matter of luck how to accurately locate and make the shear protein cut to the required position.

If we can decipher all the genes in the human DNA chain and confirm the gene expression information of each base pair, then It is very important to accurately cut the required gene fragment.

If we can hit the target at one time, we can hit the target 100 times without miss, which will undoubtedly improve the efficiency of gene editing technology thousands of times.

In the current gene editing technology, gene localization depends on transcriptase.

The transcriptase is equivalent to a radar. After transcribing the target gene, the transcriptase obtains the target information features, and then scans the gene chain to compare the target.

After the target is identified, the transcriptase that binds to the shear protein will drive the shear protein to fit the gene chain and cut the target gene.

Theoretically, this principle is completely correct. It's just The effectiveness of "radar" is relatively poor, often unable to find the target, or even find the wrong target.

Now, what Luli has to do is how to improve the radar's search ability.

But It's hard to do!

Transcriptase is a very simple protein molecule, and there is no possibility of upgrading the "hardware device".

The only way is to update the software and improve the resolution.

In order to improve the resolution of transcriptase, it is necessary to master all the gene information in the gene chain.

Well, back to the beginning.

Or we can only do gene expression detection first, and first determine the gene expression information of three billion base pairs.

Engaging in scientific research of gene completely depends on how much we know about gene!

There's a long way to go!

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