Chapter 363

Since the virtual gene chip, the experimental progress has been significantly accelerated.

The detection of gene expression information is similar to making a jigsaw puzzle. It's very difficult at the beginning. As more and more gene fragments are identified, the speed will be faster and faster.

Seeing the progress of the experiment in the virtual laboratory, Lu Li nodded slightly. According to the current process, the human gene map should be completed within a few years.

Gene detection is going on, but gene targeting technology is at a loss.

Before completing the human gene map, it is very difficult to improve the gene location from the software, that is, the accuracy of information.

Maybe There's something wrong with my thinking.

Since the ability of transcriptase is not good, then change the ability to come up!

The idea turns here, Lu Li suddenly brightens up.

Transcriptional activators, like effectors (Tales), are specific for gene targeting in human cells!

There must be other undetected "enzymes" that can replace the function of transcriptase.

So, Luli began to study all kinds of cells, bacteria and viruses.

Animal cells, plant cells, bacteria, and even viruses are used to analyze cell structure and search for enzymes with gene targeting specificity.

This process is not going well.

It's just a matter of luck to find specific enzymes in various protein molecules.

As time goes by, the specific enzyme has not been found.

Liu Qin still came to Fudan. As in reality, Liu Qin became an associate professor at Fudan School of economics.

It's just What is different from reality is that before joining Fudan, Liu Qin accepted strict and detailed political trial.

Because when Liu Qin was a doctoral student at Harvard, his interpersonal relationship was relatively simple and there was no suspicious social relationship. Moreover, father Liu's business is also based in China. He has no foreign assets, let alone business relations with foreign countries.

So There is no problem with Liu Qin's political trial.

When Liu Qin told Lu Li the news of the political trial, Lu Li was helpless. It turns out that when I'm in love with people, I still need to go through the national examination.

The arrival of Liu Qin has enriched Lu Li's weekend time, and he no longer plunges into the laboratory every weekend.

Professor he is very pleased with this. Scientists are also human beings and can't regard themselves as machines. Maybe the coming of love can inspire more.

This It's true!

In the second month after Liu Qin joined Fu Dan, Lu Li's research finally made a key breakthrough.

He found another kind of enzyme with targeting specificity - incision enzyme!

Among the type II restriction enzymes, there is a special type, which only cuts one strand of double stranded DNA to make a cut.

From the functional analysis, transcriptase is a wide range search radar, and incision enzyme is a fire control radar.

In terms of positioning accuracy, the incision enzyme is really accurate, almost hitting the mark. The problem is Without large-scale search radar, it is difficult for fire control radar to find the target.

In that case Then combine the two.

So Lu Li began to do experiments.

We can make shear protein, transcriptase and incisase, and then combine them to form a new gene editing tool.

Next, Lu Li input guide RNA into the transcriptase to determine the characteristics of the target gene. Then the new gene editing tools are injected into the cells to be edited by gene gun.

Under the electron microscope, the guide RNA on the transcriptase starts to search for the target in the gene chain. The guide RNA matches the target gene and initially locks in the general location of the target.

Then, the cleaved protein began to move towards the target.

When the cut protein moves to the target position, the fire control radar will turn on, instantly calibrate the accurate target and lock the target!

The next moment, the splicing protein moves to the target position and begins to fuse with the gene chain. The spiral gene chain is unraveled and flattened.

And then As if with a "click", the shear protein accurately cut the calibration position.

Good start! The first experiment is successful!

Later, Lu Li repeated the same experiment for hundreds of times, and the results of each experiment were 100% without any error!

It's a success!

The combination of scanning radar and fire control radar makes Luli create a new gene editing tool.

Revolutionary breakthrough in gene targeting technology!

Since then, human gene editing technology has entered a new stage.

The new gene editing tool can accurately lock the target, accurately cut the required gene fragments, and no more chance is needed.

Lu Li closed the virtual laboratory with a bright smile on his face.

Gene technology, and made a major breakthrough!

Back in his study, Lu Li sat at his computer desk and began to write his thesis."Gene targeting technology, a new tool for gene editing."

In this paper, Lu Li described a new gene editing tool with careful logic, rigorous expression and detailed experimental data.

In the original gene editing technology of shear protein + transcriptase, the "fire control radar" of incision enzyme is creatively added, which makes this new gene editing technology have extremely high gene targeting accuracy, and the efficiency of gene editing is improved thousands of times.

After writing the paper and printing it out, Lu Li walked out of the office with the paper materials.

"Teacher, I have written a new paper. Have a look."

When he came to Professor He's office, Lu Li handed over his papers.

"New paper? You Again? "

Professor he sighed in his heart that he was "so terrible" and took the paper from Lu Li.

"Gene targeting technology? A new tool for gene editing? "

Seeing the title of the paper, Professor He took a breath of air, eh Air conditioning from the air conditioner!

Did Lu Li come up with a new gene editing tool?

Restraining the shock of his heart, Professor He buried himself in the papers in his hands.

After carefully reading the paper, Professor He has clearly seen that a more efficient and more accurate gene editing technology has been born.

With this new gene editing tool, human gene editing technology has entered a new stage.

Lu Li What a genius!

First of all, we have developed a new anti-cancer technology, and now we have developed a new gene editing tool.

The pillar of the state, the blessing of the country!

Lu Li Will lead the future!

Looking up at Lu Li in front of him, professor he restrained his excitement and said to Lu Li, "go! Let's do a validation. "

"All right!"

Then they went out of the office and came to the laboratory.

In the laboratory, Lu Li repeated the experimental process in the virtual laboratory again, and carried out 100 gene editing experiments in a row.

The success rate was 100%, and the accuracy rate was 100%.

"It's amazing! It's amazing

Professor he picked up the verification data from the laboratory, and his hands were shaking. "The efficiency of gene editing has been improved thousands of times. This is a revolutionary breakthrough! "

Lu Li is smiling.

"This paper..."

Professor he looked up at Lu Li and said seriously, "delete the specific experimental steps, delete the detailed experimental data, only make theoretical statements, modify them, and send them to the world's top academic journal Nature."

With that, Professor He looked at the paper in his hand again and said, "I will submit this paper to the Chinese Academy of Sciences as an internal document."

"All right!"

Lu Li agrees with Professor He's practice of "keeping one hand.".

Science has no national boundaries, but scientists have nationalities!

We own the latest technological achievements, as for others Give a direction to you, study by yourself!

Later, Lu Li revised his paper and wrote a directional and theoretical paper. It's just At the end of the paper, Lu Li attached the conclusion of laboratory verification.

After contributing to the journal Nature, Lu Li hung up his paper on the academic Internet.

……

Across the Pacific.

In the Milligan Institute of genetics, researchers are working hard and busily.

In the research of gene technology, Milligan Gene Research Institute has enough self-confidence, they have been in the forefront of the world.

They put forward the concept of gene chip technology.

They also developed crispr-cas9, a gene editing technology.

Although Luli's new generation of anti-cancer technology has achieved success, it is only a result of technology application, and its foundation is crispr-cas9 gene editing technology.

It's just Crispr-cas9 technology, the efficiency is still too low!

It needs thousands of experiments to get a correct specimen because of inaccurate gene mapping and gene editing Miss target.

So Steven, the chief scientist at the Milligan Institute of genetics, is not satisfied.

"We're looking for a new tool for gene editing. I'll solve the problem of funds. Even if we spend tens of billions of dollars, we must develop a new gene editing tool within three years. We To lead the world

At today's morning meeting, Dr. Steven's voice was impassioned.

And then His speech was interrupted by a scream!

"I buy it!"

A man with sparse hair and deep hairline, looking at the mobile phone screen, burst out a exclamation: "Dr. Steven, you'd better look at the academic website first! Someone has developed this new gene editing tool! ""What?"

In a daze, Dr. Steven quickly took out his mobile phone and opened the academic network. As expected, he saw a piece of papers that aroused heated discussion.

"Gene targeting technology, a new tool for gene editing."

The author Luli!

Is that him?

With a thump in his heart, Steven quickly opened his paper and began to read it.

This paper theoretically describes a new combination module of gene editing tools, including splicing protein, transcriptase, and a new "targeting enzyme".

By targeting the target enzyme, accurate gene editing can be achieved.

This kind of theoretical papers, in fact, do not have much value, almost all just look at it.

However At the end of the paper, Lu Li even attached a laboratory verification report, confirming that the accuracy of the new gene editing tool is as high as 100%!

This proves that the new gene editing tool developed by Luli has been successful!

But What kind of enzyme is this "targeting enzyme"?

Vakko! Why not write down the specific enzyme?

Dr. Steven was so angry that he slapped his mobile phone on the table and pointed to the man with deep hairline who screamed before, "you, this month's bonus is gone!"

"Why?"

The man with a deep hairline has a dull face.

"Because You're playing with your cell phone in a meeting

Well, the reason It's so powerful!

The man with deep hairline curled his mouth slightly. Dr. Steven, you should be angry, right?

……

Lu Li's paper, which has not yet been officially published, has caused a strong response in the academic circles.

Countless people are gnashing their teeth at that "targeted enzyme.". What is the target enzyme? You write it for me!

There are tens of thousands of known enzymes. There are countless variants of each enzyme. How can we find this targeted enzyme if you don't write it down?

Science has no national boundaries. Why should it be so narrow? Make it public! Publish it to me!

……

The next night, another piece of news about Lu Li was broadcast on the news network of Huaxia TV station.

"Our news: after conquering cancer, Dr. Lu Li, a famous scientist in China, has developed a world-leading scientific research achievement and created a new gene editing tool. The accuracy rate of gene editing is as high as 100%, and the efficiency of gene editing has been improved 10000 times."

"The success of this technology indicates that China has reached the world leading level in the field of gene editing."

After this news broadcast, people watching TV only have one feeling in their heart, and it's Luli! Another Luli!

The Internet media immediately followed up and repeatedly reported on Luli's world leading new technology.

"Luli, the pride of the Chinese people!"

"Leading the world again, cheering for Luli!"

"Luli has created a new gene editing technology."

"With the great breakthrough of gene technology, Luli makes gene editing technology leap forward."

"This man, once again, leads the world and the times!"

In the series of reports on TV, newspapers and the Internet, Lu Li has just lost his popularity and once again become famous all over the country.

"Your surname is Lu, as expected 666!"

"God, please take my knee!"

"I'm writing my graduation thesis on" imagination of a new generation of gene editing technology. "! You've already worked it out. How can I graduate? "

"A wave of sympathy. In addition Why can't I help laughing? "

"As a researcher in genetics, I would like to talk about the significance of this technology. The emergence of this technology is similar to the invention of the steam engine. Genetic engineering has entered a new era! "

"The next era, the gene era. Lu Li has led the gene age for us

"Luli, the man leading the times!"

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